Actively Recruiting
O15-PET Imaging of Cochlear Implant Speech in Noise Processing
Led by Craig D. Workman, PhD · Updated on 2026-05-14
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how people with cochlear implants understand speech in noisy environments, aiming to uncover the brain mechanisms involved. The study compares cochlear implant users with typical hearing individuals to identify brain regions linked to speech-in-noise effort. This research uses PET neuroimaging with a radioactive tracer called O-15 to examine brain blood flow during auditory tasks in a single session. Participants include experienced cochlear implant users who have had their device activated for over a year and age-matched individuals with normal hearing. The study involves a single PET/CT scan session where participants undergo auditory stimulation to measure brain activity related to speech understanding in noise. Typical hearing participants provide a baseline for comparison. During the study, participants will have a PET scan using an injected radioactive water tracer to assess brain blood flow while listening to speech in noise. Researchers will measure brain activity to identify areas involved in processing speech under challenging conditions. The main outcome is to find cortical regions linked to speech-in-noise understanding in cochlear implant users. Participation involves one visit with neuroimaging and informed consent procedures, with monitoring for any safety concerns related to the tracer injection.
CONDITIONS
Brief Title
Cochlear Implant Speech in Noise Processing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged between 18 and 99 years
- Cochlear implant users must have their implant activated for more than one year
- Participants must be eligible under the Iowa Cochlear Implant Project VIII
- Ability to understand and willingness to sign a written informed consent
- Severe hearing loss onset after age 16 for cochlear implant group
- Age-typical hearing for normal hearing control group
You will not qualify if you...
- History of seizure disorder, head injury, neurologic, metabolic, cardiovascular disease, or previous stroke unless approved by the principal investigator
- Female participants who are pregnant (verified by urine pregnancy test before radiotracer injection)
- Use of medications that affect cerebral blood flow (such as papaverine, ginkgo biloba, acetazolamide)
- Uncontrolled illness that limits compliance with study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo PET neuroimaging to identify brain regions related to speech-in-noise processing using a radioactive tracer during auditory stimulation.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Iowa
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
C
Craig D Workman, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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