Actively Recruiting
A Cohort Study on the Association Between the Autonomic Nervous System Function and Acute GvHD After Allogeneic Hematopoietic Stem Cell Transplantation
Led by Institute of Hematology & Blood Diseases Hospital, China · Updated on 2026-01-29
60
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective observational study to explore the relationship between autonomic nervous system (ANS) function and acute graft-versus-host disease (GvHD) in patients who undergo allogeneic hematopoietic stem cell transplantation. The study aims to use ANS function measurements as early tools for classification and assessment in transplant recipients. This research is led by the Institute of Hematology & Blood Diseases Hospital in China. Participants in this study are adult patients receiving HLA-haploidentical stem cell transplants. Various tests will be conducted before and after transplantation, including heart rate response to standing, piloerection tests, and dynamic electrocardiography to evaluate ANS function. These assessments take place within one month before transplantation and again between 17 to 25 days after transplantation. The study also monitors the incidence of acute GvHD, including severe cases, within 100 days after transplantation. During the study, participants will undergo scheduled evaluations to measure heart rate response, piloerection, and electrocardiography changes. Researchers will track these physiological responses to understand their association with the development of acute GvHD. The study period includes monitoring up to 100 days post-transplant to assess disease outcomes. Participants are expected to provide informed consent and comply with study monitoring requirements throughout the observation period.
CONDITIONS
Brief Title
A Cohort Study on the Association Between the ANS Function and Acute GvHD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be over 16 years of age
- Patients receiving HLA-haploidentical transplants
- Patients must sign an informed consent form before starting the study
You will not qualify if you...
- Tandem transplantation or multiple transplantations
- Mental or medical conditions that prevent compliance with study procedures
- Factors that make participation too risky or unsuitable for the patient
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within one month before transplantation and during 17-25 days after transplantation
Participants undergo tests to assess autonomic nervous system function before and shortly after transplantation.
2 visits (in-person)
Duration - 100 days after transplantation
Participants are monitored for the incidence of acute graft-versus-host disease (GvHD) and other outcomes up to 100 days after transplantation.
Follow-up visits as per routine clinical care
Trial Site Locations
Total: 1 location
1
Institute of Hematology & Blood Diseases Hospital
Tianjin, Tianjin Municipality, China, 300000
Actively Recruiting
Research Team
Y
Yahui Feng
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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