Study on Autonomic Nervous System Function and Acute Graft-versus-Host Disease After Allogeneic Stem Cell Transplantation in Adults Receiving HLA-Haploidentical Transplants

What this Trial Is About

Researchers are conducting a prospective observational study to explore the relationship between autonomic nervous system ANS function and acute graft-versus-host disease GvHD in patients who undergo allogeneic hematopoietic stem cell transplantation. The study aims to use ANS function measurements as early tools for classification and assessment in transplant recipients. This research is led by the Institute of Hematology & Blood Diseases Hospital in China. Participants in this study are adult patients receiving HLA-haploidentical stem cell transplants. Various tests will be conducted before and after transplantation, including heart rate response to standing, piloerection tests, and dynamic electrocardiography to evaluate ANS function. These assessments take place within one month before transplantation and again between 17 to 25 days after transplantation. The study also monitors the incidence of acute GvHD, including severe cases, within 100 days after transplantation. During the study, participants will undergo scheduled evaluations to measure heart rate response, piloerection, and electrocardiography changes. Researchers will track these physiological responses to understand their association with the development of acute GvHD. The study period includes monitoring up to 100 days post-transplant to assess disease outcomes. Participants are expected to provide informed consent and comply with study monitoring requirements throughout the observation period.

A Cohort Study on the Association Between the ANS Function and Acute GvHD