Actively Recruiting
Treatment Outcomes for Patients With Cushing's Syndrome: a Prospective Data Collection Study
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-10-23
300
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are following participants with Cushing's syndrome to collect data during their routine care and to create a registry for studying long-term outcomes. This observational study focuses on patients aged 14 and older with active or treated overt Cushing's syndrome, mild adrenal Cushing's syndrome (MACS), or silent corticotroph tumors. The study is sponsored by Memorial Sloan Kettering Cancer Center and aims to gather information up to 10 years after various treatments. Participants undergo data collection before and over time after receiving surgical, medication, and/or radiation therapies. Various questionnaires are used to assess quality of life, general health, anxiety, depression, stress, impulsivity, food cravings, and related symptoms. These tools include the Cushing's QoL, Nottingham Health Profile, Hospital Anxiety and Depression Scale, Perceived Stress Scale, Barratt's Impulsivity Scale, Beck Depression Inventory, State-Trait Anxiety Inventory, Food Craving Questionnaires, Visual Analogue Scale, and the STRAP-R food variant. During the study, participants will complete these questionnaires and provide ongoing data related to their condition and treatments. Researchers monitor outcomes up to 10 years following treatment, focusing on changes in health, quality of life, and psychological symptoms. This long-term observation helps improve understanding of Cushing's syndrome outcomes under regular medical care.
CONDITIONS
Brief Title
Collecting Information About Treatment Results for Patients With Cushing's Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 14 or older
- Diagnosed with active or treated overt Cushing's syndrome from pituitary, ectopic, or adrenal tumors, mild adrenal Cushing's syndrome (MACS), or silent corticotroph tumors
- Diagnosis made by the principal investigator following Endocrine Society guidelines, clinical presentation, and judgment
- Diagnostic criteria include elevated urinary free cortisol, plasma ACTH levels, midnight salivary cortisol, dexamethasone suppression tests, pituitary MRI, or pathology confirming ACTH tumor
- In absence of MRI, surgical, or lab reports, physician's assessment notes confirming diagnosis are acceptable
You will not qualify if you...
- Diagnosis of iatrogenic Cushing's syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years after treatment
Participants with Cushing's Syndrome are observed before and over time after surgical, medication, and/or radiation therapy to collect information on treatment outcomes.
Visits occur periodically over up to 10 years after treatment
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activity)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
E
Eliza Geer, MD
M
Marc Cohen, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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