Immunology Specimen Collection Study for Cancer, Blood Disorders, and Healthy Volunteers

What this Trial Is About

This research focuses on collecting and storing blood, tissue, and bone marrow samples from patients with cancer or blood disorders, as well as healthy volunteers. The goal is to study the immune system and understand how immunotherapy works by comparing immune changes in patients receiving different treatments such as immunotherapies, chemotherapy, and targeted therapies. This study also aims to explore immune cell functions and genetic factors influencing immune recovery, especially after stem cell transplantation. Participants, including patients and healthy volunteers, provide peripheral blood samples for detailed laboratory analyses such as flow cytometry, RNA sequencing, immunohistochemistry, and mass cytometry. Patients may also provide bone marrow samples, leukopheresis specimens, and tumor biopsies obtained during routine care. These samples are used for a variety of immune system studies including genetic and proteomic testing. Throughout the study, participants are monitored for up to five years with follow-up lasting up to two years after study completion. Researchers collect clinical data alongside the biological samples to evaluate immune responses. Participants may complete questionnaires and undergo various laboratory tests to help understand immune cell activity and the effects of different treatments on the immune system.

Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers