Actively Recruiting
Protocol for Immunology Specimen Collection From Cancer Patients, Patients With Hematologic Diagnoses, and Healthy Normal Controls
Led by University of Southern California · Updated on 2026-04-02
625
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on collecting and storing blood, tissue, and bone marrow samples from patients with cancer or blood disorders, as well as healthy volunteers. The goal is to study the immune system and understand how immunotherapy works by comparing immune changes in patients receiving different treatments such as immunotherapies, chemotherapy, and targeted therapies. This study also aims to explore immune cell functions and genetic factors influencing immune recovery, especially after stem cell transplantation. Participants, including patients and healthy volunteers, provide peripheral blood samples for detailed laboratory analyses such as flow cytometry, RNA sequencing, immunohistochemistry, and mass cytometry. Patients may also provide bone marrow samples, leukopheresis specimens, and tumor biopsies obtained during routine care. These samples are used for a variety of immune system studies including genetic and proteomic testing. Throughout the study, participants are monitored for up to five years with follow-up lasting up to two years after study completion. Researchers collect clinical data alongside the biological samples to evaluate immune responses. Participants may complete questionnaires and undergo various laboratory tests to help understand immune cell activity and the effects of different treatments on the immune system.
CONDITIONS
Brief Title
Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 years or older
- Patients diagnosed with cancer or immune-mediated hematologic disorders
- Healthy volunteers without cancer, diabetes, cardiovascular disease, or non-hematologic autoimmune diseases
- Healthy volunteers not currently taking immunosuppressive medications
- Patients must have been seen at specified medical centers; healthy volunteers may be recruited without physician visits
You will not qualify if you...
- Unable to provide informed consent
- Known HIV positive status
- Healthy volunteers taking immunosuppressive medications
- Patients for whom specimen collection is deemed unsafe, such as those unable to establish venous access
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline to 5 years
Participants undergo collection of peripheral blood, bone marrow, and tissue specimens for immunology studies using various laboratory techniques.
Visits occur as needed for specimen collection during routine testing and study assessments
Duration - Up to 2 years
Participants are followed up for up to 2 years after sample collection to monitor health outcomes and study endpoints.
Follow-up visits may occur periodically during this time
Trial Site Locations
Total: 1 location
1
USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
Research Team
A
Arta Zenunovic
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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