Study to Identify Risk Factors and Develop a Prediction Model for Colorectal Cancer and Adenomas in Patients Undergoing Colonoscopy

What this Trial Is About

Researchers are studying colorectal cancer and colorectal adenomas to identify factors that best predict patients at high risk and to develop a risk prediction model. This observational study is national and multi-centre, focusing on patients undergoing colonoscopy either as part of the Bowel Cancer Screening Programme or due to symptoms. It addresses the limitation that current screening mainly considers age and aims to include other risk factors like smoking, alcohol use, family history, obesity, and gut bacteria composition. Participants will be divided into two groups one group of 10,000 patients referred for colonoscopy will provide detailed health and lifestyle information, including blood, stool, and saliva samples for various tests. Another group of 10,000 patients from the North of England will consent to be contacted for future research studies, providing some health information for this purpose. The study collects data on colonoscopy results, lifestyle factors, and patient experiences through questionnaires. During the study, patients will undergo measurements such as height, weight, and waist circumference, and complete health and food frequency questionnaires. Researchers will analyze colonoscopy findings, stool microbiome patterns, and biological samples to develop a risk prediction model for colorectal neoplasia. The study also aims to establish a platform of patients willing to participate in future research, with all results and patient consents tracked over a five-year period.

COLO-COHORT (Colorectal Cancer Cohort) Study