Actively Recruiting
Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
Led by Mayo Clinic · Updated on 2026-03-13
72
Participants Needed
3
Research Sites
501 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study compares carbon ion therapy, surgery, and proton therapy to determine if one has better disease control and fewer side effects. There are three types of radiation treatment used for pelvic bone sarcomas: surgery with or without photon/proton therapy, proton therapy alone, and carbon ion therapy alone. The purpose of this study is to compare quality of life among patients treated for pelvic bone sarcomas across the world, and to determine if carbon ion therapy improves quality of life compared to surgery and disease control compared with proton therapy.
CONDITIONS
Official Title
Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females 15 years of age or older
- Newly diagnosed with histologic confirmation of pelvic chordoma, chondrosarcoma, osteosarcoma, Ewing sarcoma with bone involvement, rhabdomyosarcoma with bone involvement, or non-RMS soft tissue sarcoma with bone involvement
- No evidence of distant sarcoma metastases as determined by clinical examination and imaging
- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less
- Patients capable of childbearing must agree to use adequate contraception
- Ability to complete questionnaires independently or with assistance
- Ability to provide written informed consent
- Chemotherapy per institutional guidelines is allowed
You will not qualify if you...
- Patients receiving palliative treatment
- Recurrent disease
- Males and females younger than 15 years of age
- Previous radiation therapy to the sarcoma site or surrounding area requiring re-irradiation
- Presence of distant sarcoma metastases
- Benign pelvic bone histologies
- Pregnant women
- Nursing women
- Men or women of childbearing potential unwilling to use adequate contraception
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Mayo Clinic in Arizona
Scottsdale, Arizona, United States, 85259
Actively Recruiting
2
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224-9980
Actively Recruiting
3
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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