Actively Recruiting

Phase 3
Age: 18Years - 99Years
All Genders
NCT06700343

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

Led by Amgen · Updated on 2026-05-11

444

Participants Needed

108

Research Sites

152 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The main objectives of the study are to demonstrate pharmacokinetics (PK) similarity between ABP 692 and Ocrelizumab (US), and ABP 692 and Ocrelizumab (EU), and to demonstrate pharmacodynamics (PD) similarity between ABP 692 and Ocrelizumab reference product (RP) based on assessment of the suppression of new active brain lesions over 24 weeks as assessed by magnetic brain imaging (MRI).

CONDITIONS

Official Title

Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)

Who Can Participate

Age: 18Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of relapsing-remitting multiple sclerosis (RRMS) by the revised McDonald Criteria 2017
  • Expanded Disability Status Scale (EDSS) score between 0 and 5.5 at screening
  • Evidence of recent multiple sclerosis activity as defined by the study
  • Neurologically stable with no relapse for 28 days or less before randomization
Not Eligible

You will not qualify if you...

  • Diagnosis of primary progressive or secondary progressive multiple sclerosis
  • Multiple sclerosis duration of 10 years or more in participants with EDSS score of 2.5 or less
  • Contraindications to study procedures or medications
  • Use of prohibited medications as defined by the study
  • Significant diseases requiring chronic treatment with systemic corticosteroids or immunosuppressants during the study
  • Current or history of significant medical conditions as described in the study
  • Abnormal laboratory blood values as defined in the study protocol

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 108 locations

1

University of South Alabama

Mobile, Alabama, United States, 36617

Actively Recruiting

2

Clinical Endpoints, LLC

Scottsdale, Arizona, United States, 85258

Actively Recruiting

3

Profound Research - Neurology Center of Southern California

Carlsbad, California, United States, 92011

Actively Recruiting

4

Mountain Neurological Research Center

Basalt, Colorado, United States, 81621

Actively Recruiting

5

Advanced Neurosciences Research, Llc

Fort Collins, Colorado, United States, 80528

Actively Recruiting

6

Hasbani Neurology

New Haven, Connecticut, United States, 06511

Actively Recruiting

7

Neurology Offices of South Florida

Boca Raton, Florida, United States, 33428

Actively Recruiting

8

Aqualane Clinical Research

Naples, Florida, United States, 34105

Actively Recruiting

9

Emerald Coast Neurology/Synergy Clinical Research

Pensacola, Florida, United States, 32504

Actively Recruiting

10

Knight Neurology

Rockledge, Florida, United States, 32955

Actively Recruiting

11

Premiere Research Institute Palm Beach

West Palm Beach, Florida, United States, 33407

Actively Recruiting

12

Hawaii Pacific Neuroscience

Honolulu, Hawaii, United States, 96817

Actively Recruiting

13

University of Kansas Medical Center

Kansas City, Kansas, United States, 66160

Actively Recruiting

14

Henry Ford Health

Detroit, Michigan, United States, 48202

Actively Recruiting

15

Michigan Institute For Neurological Disorders (Glendale Neurological Associates) - Farmington Hills

Farmington, Michigan, United States, 48334-2979

Actively Recruiting

16

JFK Medical Center

Edison, New Jersey, United States, 08820

Actively Recruiting

17

Hackensack Meridian Health

Paramus, New Jersey, United States, 07652

Actively Recruiting

18

University of NM/Mind Imaging center

Albuquerque, New Mexico, United States, 87131

Actively Recruiting

19

Triad Neurological Associates

Winston-Salem, North Carolina, United States, 27103

Actively Recruiting

20

Singlepoint Healthcare Opco, LLC

Columbus, Ohio, United States, 43235

Actively Recruiting

21

NDx Clinical Research, Inc

Dayton, Ohio, United States, 45459

Actively Recruiting

22

Premier Neurology, PC

Greenville, South Carolina, United States, 29650

Actively Recruiting

23

Hope Neurology

Knoxville, Tennessee, United States, 37922

Actively Recruiting

24

Vanderbilt University Medical Center (VUMC)

Nashville, Tennessee, United States, 37215

Actively Recruiting

25

Lone Star Neurology

Frisco, Texas, United States, 75035

Actively Recruiting

26

Froedtert Hospital-Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

Actively Recruiting

27

Algemeen Ziekenhuis Delta

Roeselare, West-Vlaanderen, Belgium, 8800

Actively Recruiting

28

MS-Netwerk Limburg - Revalidatie & MS Centrum

Overpelt, Belgium, 3900

Actively Recruiting

29

Diagnostic Consultative Center Convex Ltd

Sofia, Sofiiska, Bulgaria, 1680

Actively Recruiting

30

UMHAT Dr.Georgi Stranski EAD

Pleven, Bulgaria, 5800

Actively Recruiting

31

University Multi-Profile Hospital for Active Treatment (UMHAT) St. Ivan Rilski

Sofia, Bulgaria, 1431

Actively Recruiting

32

Medical Center Hera EOOD

Sofia, Bulgaria, 1510

Actively Recruiting

33

UMHATEM N.I. Pirogov

Sofia, Bulgaria, 1606

Actively Recruiting

34

Foothills Medical Centre

Calgary, Alberta, Canada, T2N 2T9

Actively Recruiting

35

The Ottawa Hospital Research Institute

Ottawa, Ontario, Canada, K1H 8L6

Actively Recruiting

36

Sestre milosrdnice University Hospital Center

Zagreb, Croatia, 10000

Actively Recruiting

37

University Hospital Centre Zagreb

Zagreb, Croatia, 10000

Actively Recruiting

38

Fakultni nemocnice u sv. Anny v Brne

Brno, Czechia, 656 91

Actively Recruiting

39

Fakultni Nemocnice Hradec Kralove

Hradec Králové, Czechia, 500 05

Actively Recruiting

40

Privatni ordinace neurologie

Hradec Králové, Czechia, 50003

Actively Recruiting

41

Regional Hospital Jihlava

Jihlava, Czechia, 58601

Actively Recruiting

42

Nemocnice Teplice

Teplice, Czechia, 415 01

Actively Recruiting

43

Aarhus Universitetshospital, Skejby

Aarhus N, Central Jutland, Denmark, 8200

Actively Recruiting

44

Sydvestjysk Sygehus

Esbjerg, Region Syddanmark, Denmark, 6700

Actively Recruiting

45

Dansk Multipel Sklerose Center

Glostrup Municipality, Denmark, 2600

Actively Recruiting

46

Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau

Nîmes, France, 30029

Actively Recruiting

47

LTD Pineo Medical Ecosystem

Tbilisi, Georgia, 0114

Actively Recruiting

48

Jo Ann University Hospital

Tbilisi, Georgia, 0159

Actively Recruiting

49

Zentrum fur klinische Forschung Dr.Scholl

Bad Homburg, Germany, 61348

Actively Recruiting

50

Studienzentrum Dr. Bischof GmbH

Böblingen, Germany, 71034

Actively Recruiting

51

University Hospital Carl Gustav Carus

Dresden, Germany, 01307

Actively Recruiting

52

Curiositas-ad-Sanum GmbH

Ebersberg, Germany, 85560

Actively Recruiting

53

Universitaetsklinikum Essen

Essen, Germany, 45147

Actively Recruiting

54

Klinische Forschung Hamburg GmbH

Hamburg, Germany, 20253

Actively Recruiting

55

Multipel Studies Institut fuer klinische Studien GbR

Hamburg, Germany, 22179

Actively Recruiting

56

Universitaetsklinikum Heidelberg

Heidelberg, Germany, 69120

Actively Recruiting

57

Universitaetsklinikum Leipzig

Leipzig, Germany, 04103

Actively Recruiting

58

Praxisgemeinschaft fuer Neurologie, Psychiatrie und Psychotherapie - Regensburg

Regensburg, Germany, 93059

Completed

59

ZNS Siegen GmbH

Siegen, Germany, 57076

Actively Recruiting

60

Neuropraxis Munchen Sud - Unterhaching

Unterhaching, Germany, 82008

Actively Recruiting

61

Bellaria-Maggiore Hospital-Azienda USL Bologna

Bologna, Italy, 40139

Actively Recruiting

62

Casa di Cura Privata del Policlinico Igea S.p.A

Milan, Italy, 20144

Actively Recruiting

63

Universita degli Studi della Campania Luigi Vanvitelli - Clinica Neurologia II - Centro Sclerosi Mul

Naples, Italy, 80138

Actively Recruiting

64

Ospedale Sant'Andrea Hospital

Rome, Italy, 00189

Actively Recruiting

65

Hospital of Lithuanian University of Health Sciences Kaunas

Kaunas, Lithuania, 50161

Actively Recruiting

66

Klaipedas University Hospital

Klaipėda, Lithuania, LT-92288

Actively Recruiting

67

Vitamed Galaj i Cichomski sp.j.

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-079

Actively Recruiting

68

MA-LEK Clinical Sp. z o.o.

Katowice, Silesian Voivodeship, Poland, 40-571

Actively Recruiting

69

Neuro-Care

Katowice, Silesian Voivodeship, Poland, 40-749

Actively Recruiting

70

Neurocentrum Bydgoszcz

Bydgoszcz, Poland, 85-796

Actively Recruiting

71

Neuro Medic Clinic

Katowice, Poland, 40-686

Actively Recruiting

72

Resmedica Sp. z o.o.

Kielce, Poland, 25-726

Actively Recruiting

73

Krakowska Akademia Neurologii

Krakow, Poland, 31-505

Actively Recruiting

74

Centrum Neurologii Krzysztof Selmaj

Lodz, Poland, 90-324

Actively Recruiting

75

NZOZ Neuromed M. i M. Nastaj Sp.P

Lublin, Poland, 20-064

Actively Recruiting

76

Nzoz Neuro-Kard Ilkowski I Partnerzy Spolka Partnerska Lekarzy

Poznan, Poland, 61-853

Actively Recruiting

77

Centrum Medyczne Neuroprotect

Warsaw, Poland, 01-684

Actively Recruiting

78

MTZ Clinical Research Powered by Pratia

Warsaw, Poland, 02-172

Actively Recruiting

79

ARENSIA Clinics

Bucharest, Romania, 011658

Actively Recruiting

80

ARENSIA Exploratory Medicine at County Hospital Cluj-Napoca

Cluj-Napoca, Romania, 400006

Actively Recruiting

81

Clinical Hospital Center Zvezdara

Belgrade, Serbia, 11000

Actively Recruiting

82

University Clinical Centre of Kragujevac

Kragujevac, Serbia, 34000

Actively Recruiting

83

Clinic of Neurology, University Clinical Center Nis

Niš, Serbia, 18000

Actively Recruiting

84

Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)

Bratislava, Slovakia, 82626

Actively Recruiting

85

Neurologicka ambulancia Empathy, s.r.o.

Bratislava, Slovakia, 85101

Actively Recruiting

86

Fakultna Nemocnica Trnava

Trnava, Slovakia, 91775

Actively Recruiting

87

University Medical Centre Ljubljana-UKCL

Ljubljana, Slovenia, 1110

Actively Recruiting

88

Hospital Universitario Fundacion Alcorcon

Alcorcón, Spain, 28922

Actively Recruiting

89

Hospital Clinic de Barcelona - Institut Clinic de Malalties Hematologiques i Oncologiques (ICMHO)

Barcelona, Spain, 08036

Actively Recruiting

90

Hospital Vithas Nisa Sevilla

Castilleja de la Cuesta, Spain, 41950

Actively Recruiting

91

Hospital de Denia Marina Salud

Dénia, Spain, 03700

Actively Recruiting

92

Hospital General Universitario Gregorio Maranon (HGUGM)

Madrid, Spain, 28007

Actively Recruiting

93

Vithas Hospital Parque San Antonio

Malag, Spain, 29016

Actively Recruiting

94

Hospital Regional Universitario de Malaga

Málaga, Spain, 29010

Actively Recruiting

95

Hospital Santa Caterina

Salt, Spain, 17190

Actively Recruiting

96

Universidad de Sevilla - Hospital Universitario Virgen Macarena

Seville, Spain, 41009

Actively Recruiting

97

Hospital Universitario de Torrejon

Torrejón de Ardoz, Spain, 28850

Actively Recruiting

98

Hospital Universitario Doctor Peset

Valencia, Spain, 46017

Actively Recruiting

99

Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulev

Valencia, Spain, 46026

Actively Recruiting

100

Hospital Alvaro Cunqueiro

Vigo, Spain, 36312

Actively Recruiting

101

MS Center Research Unit, Sahlgrenska University Hospital

Gothenburg, Sweden, 413 45

Actively Recruiting

102

Academic Specialist Center

Stockholm, Sweden, SE113 65

Completed

103

Universitaetsspital Bern - Inselspital

Bern, Switzerland, 3010

Actively Recruiting

104

Ospedale Regionale di Lugano, Sede Civico

Lugano, Switzerland, 6903

Actively Recruiting

105

Yeditepe University Kosuyolu Hospital

Kadıköy, Istanbul, Turkey (Türkiye), 34718

Actively Recruiting

106

Uludag University Medical Faculty

Bursa, Turkey (Türkiye), 16059

Actively Recruiting

107

Ondokuz Mayis University Health Practice and Research Hospital

Samsun, Turkey (Türkiye), 55280

Actively Recruiting

108

Arencia Exploratory Medicine

Kyiv, Ukraine, 01135

Actively Recruiting

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Research Team

A

Amgen Call Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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