Actively Recruiting
A Randomized, Double-blind, Parallel-group Study to Compare Pharmacokinetics, Pharmacodynamics, Clinical Effects, and Safety Between ABP 692 and Ocrevus4 (Ocrelizumab) in Subjects With Relapsing-remitting Multiple Sclerosis
Led by Amgen · Updated on 2026-05-29
444
Participants Needed
109
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the pharmacokinetics and pharmacodynamics of ABP 692 compared to Ocrelizumab in people with relapsing-remitting multiple sclerosis (RRMS). The study aims to show that ABP 692 and Ocrelizumab have similar effects by measuring the suppression of new active brain lesions over 24 weeks using MRI scans. This is a phase 3, randomized, double-blind study sponsored by Amgen. Participants with RRMS will receive intravenous infusions of either ABP 692 or Ocrelizumab from the US or EU. The ABP 692 group receives 300 mg on Day 1 and Day 15, followed by 600 mg at Week 24. The Ocrelizumab (US) group receives 300 mg doses on Day 1 and Day 15, then switches to 600 mg of ABP 692 at Week 24. The Ocrelizumab (EU) group receives 300 mg on Day 1 and Day 15, then 600 mg at Week 24. Throughout the study, participants will undergo blood tests and MRI scans to monitor drug levels, brain lesions, and immune cell counts. Researchers will assess safety by tracking adverse events up to 96 weeks. The main outcomes include measuring drug concentration in the blood and counting new brain lesions during the first 24 weeks. Participants will be followed for safety and treatment effects up to nearly two years from the start of the study.
CONDITIONS
Brief Title
Comparison Between ABP 692 and Ocrevus® (Ocrelizumab)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of relapsing-remitting multiple sclerosis according to the revised McDonald Criteria 2017
- Expanded Disability Status Scale score between 0 and 5.5 inclusive at screening
- Evidence of recent multiple sclerosis activity as defined by the study
- Neurologically stable with no relapse within 28 days before randomization
You will not qualify if you...
- Diagnosis of primary progressive or secondary progressive multiple sclerosis
- Multiple sclerosis duration of 10 years or more if Expanded Disability Status Scale score is 2.5 or less at screening
- Contraindications to study procedures or medications
- Use of prohibited medications as defined by the study
- Significant concomitant disease requiring chronic systemic corticosteroids or immunosuppressants during the study
- Current or history of significant medical conditions as described in the study
- Abnormal laboratory blood values as defined by the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 weeks
Participants receive intravenous infusions of either ABP 692 or Ocrelizumab for relapsing-remitting multiple sclerosis. The initial treatment includes two 300 mg doses given on Day 1 and Day 15, followed by a 600 mg dose at Week 24.
3 infusion visits: Day 1, Day 15, and Week 24
Duration - Up to 72 weeks after Week 24 infusion (total up to 96 weeks)
Participants are monitored for safety, clinical effects, and disease activity after treatment infusions.
Periodic visits for assessments up to Week 96
Trial Site Locations
Total: 109 locations
1
University of South Alabama
Mobile, Alabama, United States, 36617
Actively Recruiting
2
Clinical Endpoints, LLC
Scottsdale, Arizona, United States, 85258
Actively Recruiting
3
Profound Research - Neurology Center of Southern California
Carlsbad, California, United States, 92011
Actively Recruiting
4
Mountain Neurological Research Center
Basalt, Colorado, United States, 81621
Actively Recruiting
5
Advanced Neurosciences Research, Llc
Fort Collins, Colorado, United States, 80528
Actively Recruiting
6
Hasbani Neurology
New Haven, Connecticut, United States, 06511
Actively Recruiting
7
Neurology Offices of South Florida
Boca Raton, Florida, United States, 33428
Actively Recruiting
8
Aqualane Clinical Research
Naples, Florida, United States, 34105
Actively Recruiting
9
Emerald Coast Neurology/Synergy Clinical Research
Pensacola, Florida, United States, 32504
Actively Recruiting
10
Knight Neurology
Rockledge, Florida, United States, 32955
Actively Recruiting
11
Premiere Research Institute Palm Beach
West Palm Beach, Florida, United States, 33407
Actively Recruiting
12
Hawaii Pacific Neuroscience
Honolulu, Hawaii, United States, 96817
Actively Recruiting
13
Rush University Medical Center, Rush University Cancer Center
Chicago, Illinois, United States, 60612-3841
Completed
14
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
15
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
16
Michigan Institute For Neurological Disorders (Glendale Neurological Associates) - Farmington Hills
Farmington, Michigan, United States, 48334-2979
Actively Recruiting
17
JFK Medical Center
Edison, New Jersey, United States, 08820
Actively Recruiting
18
Hackensack Meridian Health
Paramus, New Jersey, United States, 07652
Actively Recruiting
19
University of NM/Mind Imaging center
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
20
Triad Neurological Associates
Winston-Salem, North Carolina, United States, 27103
Actively Recruiting
21
Singlepoint Healthcare Opco, LLC
Columbus, Ohio, United States, 43235
Actively Recruiting
22
NDx Clinical Research, Inc
Dayton, Ohio, United States, 45459
Actively Recruiting
23
Premier Neurology, PC
Greenville, South Carolina, United States, 29650
Actively Recruiting
24
Hope Neurology
Knoxville, Tennessee, United States, 37922
Actively Recruiting
25
Vanderbilt University Medical Center (VUMC)
Nashville, Tennessee, United States, 37215
Actively Recruiting
26
Lone Star Neurology
Frisco, Texas, United States, 75035
Actively Recruiting
27
Froedtert Hospital-Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
28
Algemeen Ziekenhuis Delta
Roeselare, West-Vlaanderen, Belgium, 8800
Actively Recruiting
29
MS-Netwerk Limburg - Revalidatie & MS Centrum
Overpelt, Belgium, 3900
Actively Recruiting
30
Diagnostic Consultative Center Convex Ltd
Sofia, Sofiiska, Bulgaria, 1680
Actively Recruiting
31
UMHAT Dr.Georgi Stranski EAD
Pleven, Bulgaria, 5800
Actively Recruiting
32
University Multi-Profile Hospital for Active Treatment (UMHAT) St. Ivan Rilski
Sofia, Bulgaria, 1431
Actively Recruiting
33
Medical Center Hera EOOD
Sofia, Bulgaria, 1510
Actively Recruiting
34
UMHATEM N.I. Pirogov
Sofia, Bulgaria, 1606
Actively Recruiting
35
Foothills Medical Centre
Calgary, Alberta, Canada, T2N 2T9
Actively Recruiting
36
The Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
37
Sestre milosrdnice University Hospital Center
Zagreb, Croatia, 10000
Actively Recruiting
38
University Hospital Centre Zagreb
Zagreb, Croatia, 10000
Actively Recruiting
39
Fakultni nemocnice u sv. Anny v Brne
Brno, Czechia, 656 91
Actively Recruiting
40
Fakultni Nemocnice Hradec Kralove
Hradec Králové, Czechia, 500 05
Actively Recruiting
41
Privatni ordinace neurologie
Hradec Králové, Czechia, 50003
Actively Recruiting
42
Regional Hospital Jihlava
Jihlava, Czechia, 58601
Actively Recruiting
43
Nemocnice Teplice
Teplice, Czechia, 415 01
Actively Recruiting
44
Aarhus Universitetshospital, Skejby
Aarhus N, Central Jutland, Denmark, 8200
Actively Recruiting
45
Sydvestjysk Sygehus
Esbjerg, Region Syddanmark, Denmark, 6700
Actively Recruiting
46
Dansk Multipel Sklerose Center
Glostrup Municipality, Denmark, 2600
Actively Recruiting
47
Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau
Nîmes, France, 30029
Actively Recruiting
48
LTD Pineo Medical Ecosystem
Tbilisi, Georgia, 0114
Actively Recruiting
49
Jo Ann University Hospital
Tbilisi, Georgia, 0159
Actively Recruiting
50
Zentrum fur klinische Forschung Dr.Scholl
Bad Homburg, Germany, 61348
Actively Recruiting
51
Studienzentrum Dr. Bischof GmbH
Böblingen, Germany, 71034
Actively Recruiting
52
University Hospital Carl Gustav Carus
Dresden, Germany, 01307
Actively Recruiting
53
Curiositas-ad-Sanum GmbH
Ebersberg, Germany, 85560
Actively Recruiting
54
Universitaetsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
55
Klinische Forschung Hamburg GmbH
Hamburg, Germany, 20253
Actively Recruiting
56
Multipel Studies Institut fuer klinische Studien GbR
Hamburg, Germany, 22179
Actively Recruiting
57
Universitaetsklinikum Heidelberg
Heidelberg, Germany, 69120
Actively Recruiting
58
Universitaetsklinikum Leipzig
Leipzig, Germany, 04103
Actively Recruiting
59
Praxisgemeinschaft fuer Neurologie, Psychiatrie und Psychotherapie - Regensburg
Regensburg, Germany, 93059
Completed
60
ZNS Siegen GmbH
Siegen, Germany, 57076
Actively Recruiting
61
Neuropraxis Munchen Sud - Unterhaching
Unterhaching, Germany, 82008
Actively Recruiting
62
Bellaria-Maggiore Hospital-Azienda USL Bologna
Bologna, Italy, 40139
Actively Recruiting
63
Casa di Cura Privata del Policlinico Igea S.p.A
Milan, Italy, 20144
Actively Recruiting
64
Universita degli Studi della Campania Luigi Vanvitelli - Clinica Neurologia II - Centro Sclerosi Mul
Naples, Italy, 80138
Actively Recruiting
65
Ospedale Sant'Andrea Hospital
Rome, Italy, 00189
Actively Recruiting
66
Hospital of Lithuanian University of Health Sciences Kaunas
Kaunas, Lithuania, 50161
Actively Recruiting
67
Klaipedas University Hospital
Klaipėda, Lithuania, LT-92288
Actively Recruiting
68
Vitamed Galaj i Cichomski sp.j.
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-079
Actively Recruiting
69
MA-LEK Clinical Sp. z o.o.
Katowice, Silesian Voivodeship, Poland, 40-571
Actively Recruiting
70
Neuro-Care
Katowice, Silesian Voivodeship, Poland, 40-749
Actively Recruiting
71
Neurocentrum Bydgoszcz
Bydgoszcz, Poland, 85-796
Actively Recruiting
72
Neuro Medic Clinic
Katowice, Poland, 40-686
Actively Recruiting
73
Resmedica Sp. z o.o.
Kielce, Poland, 25-726
Actively Recruiting
74
Krakowska Akademia Neurologii
Krakow, Poland, 31-505
Actively Recruiting
75
Centrum Neurologii Krzysztof Selmaj
Lodz, Poland, 90-324
Actively Recruiting
76
NZOZ Neuromed M. i M. Nastaj Sp.P
Lublin, Poland, 20-064
Actively Recruiting
77
Nzoz Neuro-Kard Ilkowski I Partnerzy Spolka Partnerska Lekarzy
Poznan, Poland, 61-853
Actively Recruiting
78
Centrum Medyczne Neuroprotect
Warsaw, Poland, 01-684
Actively Recruiting
79
MTZ Clinical Research Powered by Pratia
Warsaw, Poland, 02-172
Actively Recruiting
80
ARENSIA Clinics
Bucharest, Romania, 011658
Actively Recruiting
81
ARENSIA Exploratory Medicine at County Hospital Cluj-Napoca
Cluj-Napoca, Romania, 400006
Actively Recruiting
82
Clinical Hospital Center Zvezdara
Belgrade, Serbia, 11000
Actively Recruiting
83
University Clinical Centre of Kragujevac
Kragujevac, Serbia, 34000
Actively Recruiting
84
Clinic of Neurology, University Clinical Center Nis
Niš, Serbia, 18000
Actively Recruiting
85
Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)
Bratislava, Slovakia, 82626
Actively Recruiting
86
Neurologicka ambulancia Empathy, s.r.o.
Bratislava, Slovakia, 85101
Actively Recruiting
87
Fakultna Nemocnica Trnava
Trnava, Slovakia, 91775
Actively Recruiting
88
University Medical Centre Ljubljana-UKCL
Ljubljana, Slovenia, 1110
Actively Recruiting
89
Hospital Universitario Fundacion Alcorcon
Alcorcón, Spain, 28922
Actively Recruiting
90
Hospital Clinic de Barcelona - Institut Clinic de Malalties Hematologiques i Oncologiques (ICMHO)
Barcelona, Spain, 08036
Actively Recruiting
91
Hospital Vithas Nisa Sevilla
Castilleja de la Cuesta, Spain, 41950
Actively Recruiting
92
Hospital de Denia Marina Salud
Dénia, Spain, 03700
Actively Recruiting
93
Hospital General Universitario Gregorio Maranon (HGUGM)
Madrid, Spain, 28007
Actively Recruiting
94
Vithas Hospital Parque San Antonio
Malag, Spain, 29016
Actively Recruiting
95
Hospital Regional Universitario de Malaga
Málaga, Spain, 29010
Actively Recruiting
96
Hospital Santa Caterina
Salt, Spain, 17190
Actively Recruiting
97
Universidad de Sevilla - Hospital Universitario Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
98
Hospital Universitario de Torrejon
Torrejón de Ardoz, Spain, 28850
Actively Recruiting
99
Hospital Universitario Doctor Peset
Valencia, Spain, 46017
Actively Recruiting
100
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulev
Valencia, Spain, 46026
Actively Recruiting
101
Hospital Alvaro Cunqueiro
Vigo, Spain, 36312
Actively Recruiting
102
MS Center Research Unit, Sahlgrenska University Hospital
Gothenburg, Sweden, 413 45
Actively Recruiting
103
Academic Specialist Center
Stockholm, Sweden, SE113 65
Completed
104
Universitaetsspital Bern - Inselspital
Bern, Switzerland, 3010
Actively Recruiting
105
Ospedale Regionale di Lugano, Sede Civico
Lugano, Switzerland, 6903
Actively Recruiting
106
Yeditepe University Kosuyolu Hospital
Kadıköy, Istanbul, Turkey (Türkiye), 34718
Actively Recruiting
107
Uludag University Medical Faculty
Bursa, Turkey (Türkiye), 16059
Actively Recruiting
108
Ondokuz Mayis University Health Practice and Research Hospital
Samsun, Turkey (Türkiye), 55280
Actively Recruiting
109
Arencia Exploratory Medicine
Kyiv, Ukraine, 01135
Actively Recruiting
Research Team
A
Amgen Call Center
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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