Actively Recruiting
Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Led by University Hospital, Basel, Switzerland · Updated on 2024-12-16
300
Participants Needed
1
Research Sites
534 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
S
Swiss National Science Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project is to: 1. Quantify differences in axonal integrity and organization in aMS versus naPMS patients. 2. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. 3. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.
CONDITIONS
Official Title
Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with active relapsing-remitting multiple sclerosis (RRMS) with at least one clinical relapse or MRI activity in the past year
- Patients diagnosed with non-active progressive multiple sclerosis (PMS) including primary progressive MS (PPMS) or secondary progressive MS (SPMS) with no clinical relapses or MRI activity in the past year
- Healthy controls aged 18 to 80 years
- No other neurological or psychiatric disorders
- Aged between 18 and 80 years
You will not qualify if you...
- Pregnancy
- Contraindications to MRI such as claustrophobia, metallic implants, or pacemakers
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Basel, Department of Neurology
Basel, Switzerland, 4031
Actively Recruiting
Research Team
C
Cristina Granziera, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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