Actively Recruiting
Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain : a Prospective Study With Long Term Follow up
Led by Clinique du Sport, Bordeaux Mérignac · Updated on 2025-09-18
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing two treatments for persistent lumbar radicular pain (LRP) caused by a herniated disc. The study evaluates the long-term effects of CT-guided epidural steroid injections (ESI), a common treatment with rare serious complications, versus platelet-rich plasma (PRP) injections, which may promote healing and reduce inflammation by delivering growth factors and cytokines. A previous study found PRP to be as effective as ESI without major complications. This prospective study aims to assess these treatments over two years. Participants will receive either interlaminar CT-guided epidural steroid injections or interlaminar CT-guided epidural platelet-rich plasma injections. The PRP treatment involves collecting blood, processing it to concentrate plasma, and then injecting it. The trial is randomized, with participants assigned to either the steroid or PRP group. The treatments are given under CT guidance to target the affected area. Throughout the study, participants' functional ability will be measured before the procedure and at multiple follow-up points: 6 weeks, 6 months, 1 year, and 2 years after treatment. Pain levels will also be evaluated at these same intervals. Researchers will monitor outcomes to compare the effectiveness and safety of the two treatments over the long term.
CONDITIONS
Brief Title
Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of unilateral resistant lumbar radicular pain associated with a herniated disc on MRI
- Resistance to appropriate medical treatment for at least 6 weeks
- Adults aged 18 years or older
You will not qualify if you...
- Presence of infections
- Previous percutaneous corticosteroid injections
- Current systemic corticosteroid treatment
- Immune deficiencies
- Allergy to contrast medium used
- Pregnancy or breastfeeding
- History of allergies to anesthetics or corticosteroids
- Anticoagulant or antiplatelet treatment, or blood disorders
- Use of NSAIDs within two weeks prior to the procedure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure with follow-up assessments up to 2 years
Participants receive either an interlaminar CT guided epidural steroid injection or platelet-rich plasma injection as treatment for lumbar radicular pain.
1 treatment visit and multiple follow-up visits at 6 weeks, 6 months, 1 year, and 2 years
Trial Site Locations
Total: 1 location
1
Clinique du Sport
Mérignac, France, 33700
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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