Long-term Study Comparing CT-Guided Epidural Platelet-Rich Plasma and Steroid Injections for Lumbar Radicular Pain from Herniated Disc

What this Trial Is About

Researchers are comparing two treatments for persistent lumbar radicular pain LRP caused by a herniated disc. The study evaluates the long-term effects of CT-guided epidural steroid injections ESI, a common treatment with rare serious complications, versus platelet-rich plasma PRP injections, which may promote healing and reduce inflammation by delivering growth factors and cytokines. A previous study found PRP to be as effective as ESI without major complications. This prospective study aims to assess these treatments over two years. Participants will receive either interlaminar CT-guided epidural steroid injections or interlaminar CT-guided epidural platelet-rich plasma injections. The PRP treatment involves collecting blood, processing it to concentrate plasma, and then injecting it. The trial is randomized, with participants assigned to either the steroid or PRP group. The treatments are given under CT guidance to target the affected area. Throughout the study, participants functional ability will be measured before the procedure and at multiple follow-up points 6 weeks, 6 months, 1 year, and 2 years after treatment. Pain levels will also be evaluated at these same intervals. Researchers will monitor outcomes to compare the effectiveness and safety of the two treatments over the long term.

Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain