Study Comparing Live Birth Rates in Natural Cycle Single Euploid Frozen Embryo Transfers With and Without Luteal Phase Support in Women Aged 18 to 40

What this Trial Is About

Researchers are evaluating whether transferring a single genetically normal embryo during a natural menstrual cycle without routine luteal phase support LPS is not worse than transferring with LPS. This study focuses on women with regular ovulatory cycles who have at least one genetically tested embryo available, aiming to simplify treatment and improve participant comfort if the outcomes are similar. Participants are randomly assigned to one of two groups. Both groups will have intermittent ultrasounds and blood tests measuring hormone levels to monitor ovulation. In the group without LPS, embryo transfer is scheduled five days after ovulation without additional progesterone support. The group receiving LPS will be given vaginal progesterone starting on the day of embryo transfer and continuing until the pregnancy test, with support extended to seven weeks if pregnancy occurs. Throughout the study, participants will undergo multiple hormone measurements and ultrasounds to track follicular growth and hormone levels before and after embryo transfer. Pregnancy confirmation will occur via blood tests 10 days after transfer. The study will measure implantation rate, clinical pregnancy rate, live birth rate, and hormone levels at specific time points. Participant involvement includes frequent clinic visits for monitoring and blood draws over the course of the treatment cycle and early pregnancy period.

Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support