Comparison of V-NOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) Mesh-Free Sacrocolpopexy and Laparoscopic Mesh-Free Sacrocolpopexy

What this Trial Is About

Pelvic organ prolapse (POP) is a common condition affecting women, especially as they age and have had children, often requiring surgery. This research is evaluating and comparing two minimally invasive surgical methods for repairing POP without using synthetic mesh: Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) mesh-free sacrocolpopexy and laparoscopic mesh-free sacrocolpopexy. The study aims to see if the V-NOTES technique offers similar or better surgical outcomes, safety, and patient satisfaction compared to the traditional laparoscopic approach. The two treatments being studied are mesh-free sacrocolpopexy performed through V-NOTES and through conventional laparoscopy. Both procedures are done by experienced surgeons. The study will analyze factors like operation time, complications during and after surgery, hospital stay length, pain levels, anatomical repair success, and patient satisfaction. Participants will be randomly assigned to one of these two surgical methods. Participants will be assessed before surgery and then followed up for at least six months after the procedure. Researchers will measure changes in the Pelvic Organ Prolapse Quantification (POP-Q) stage, sexual function using the PISQ-12 score, and pelvic floor distress with the PFDI-20 score from baseline to six months post-surgery. Safety, anatomical and functional outcomes, and patient satisfaction will be closely monitored throughout the study duration, which is expected to last until January 2026.

Comparison of V-NOTES and Laparoscopic Mesh-Free Sacrocolpopexy Techniques