Actively Recruiting
Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis
Led by University of Turku · Updated on 2025-08-24
110
Participants Needed
4
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Turku
Lead Sponsor
T
Turku University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the complex causes and cellular makeup of hip osteoarthritis (OA) using advanced single-cell and spatial omics technologies. The study aims to identify different cell types in synovial tissues and blood samples from OA patients, compare these to non-arthritic tissues, explore inflammatory responses, uncover key molecular pathways, and differentiate OA subtypes. A sub-study also compares tissue and blood from patients with rheumatoid arthritis (RA) to better understand differences in disease mechanisms. The study involves three groups: adults with hip OA undergoing elective total hip arthroplasty, adults with hip RA undergoing elective total hip arthroplasty, and non-arthritic adults undergoing trauma-based emergency total hip arthroplasty as controls. Researchers collect tissue and blood samples for detailed analysis using single-cell RNA sequencing and spatial omics to map the transcriptome and proteome while preserving tissue structure. Participants will undergo hip joint replacement surgery and provide samples for molecular analysis. The study timeline includes characterizing cell populations from early 2025 to late 2026, mapping cellular landscapes through 2026, identifying molecular pathways through 2027, and comparing RA and OA disease mechanisms through 2028. Researchers also study potential blood biomarkers and OA subtypes. The total duration spans several years with ongoing assessments and molecular mapping.
CONDITIONS
Brief Title
Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 74 years
- Patients with osteoarthritis in the hip joint undergoing elective total hip arthroplasty
- Patients with rheumatoid arthritis in the hip joint undergoing elective total hip arthroplasty (Rheumatoid sub-study)
- Non-arthritis patients undergoing trauma-based emergency total hip arthroplasty (controls)
You will not qualify if you...
- Body mass index must be below 35
- Age less than 18 or greater than 74 years
- Osteoarthritis patients may not have diabetes, rheumatoid arthritis, or metabolic syndrome
- Rheumatoid arthritis sub-study follows the same exclusion criteria except diabetes and metabolic syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery and immediate recovery period
Participants undergo total hip arthroplasty (hip joint replacement surgery) as part of their routine care, either elective for osteoarthritis and rheumatoid arthritis cases or emergency for trauma cases.
1 surgery visit (in-person)
Duration - During surgery
Samples from synovial tissues and blood are collected during surgery to study cell populations, molecular pathways, and biomarkers related to osteoarthritis and rheumatoid arthritis.
Sample collection occurs during surgery visit
Duration - Up to 4 years until study completion in December 2028
Participants' samples and data are observed and analyzed over time to characterize cell populations, compare disease mechanisms, and identify biomarkers and osteoarthritis endotypes.
No additional visits required; data collection is observational
Trial Site Locations
Total: 4 locations
1
PET-centre, University of Turku
Turku, Southwest Finland, Finland
Active, Not Recruiting
2
Turku Bioscience, University of Turku
Turku, Southwest Finland, Finland
Active, Not Recruiting
3
Turku University Hospital
Turku, Southwest Finland, Finland
Actively Recruiting
4
Helsinki University Hospital
Espoo, Uusimaa, Finland
Actively Recruiting
Research Team
L
Lea Mikkola, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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