Understanding the Molecular Causes and Cell Types in Hip Osteoarthritis Using Advanced Tissue Analysis Comparing Hip Osteoarthritis and Rheumatoid Arthritis Through Hip Replacement Surgery

What this Trial Is About

Researchers are investigating the complex causes and cellular makeup of hip osteoarthritis OA using advanced single-cell and spatial omics technologies. The study aims to identify different cell types in synovial tissues and blood samples from OA patients, compare these to non-arthritic tissues, explore inflammatory responses, uncover key molecular pathways, and differentiate OA subtypes. A sub-study also compares tissue and blood from patients with rheumatoid arthritis RA to better understand differences in disease mechanisms. The study involves three groups adults with hip OA undergoing elective total hip arthroplasty, adults with hip RA undergoing elective total hip arthroplasty, and non-arthritic adults undergoing trauma-based emergency total hip arthroplasty as controls. Researchers collect tissue and blood samples for detailed analysis using single-cell RNA sequencing and spatial omics to map the transcriptome and proteome while preserving tissue structure. Participants will undergo hip joint replacement surgery and provide samples for molecular analysis. The study timeline includes characterizing cell populations from early 2025 to late 2026, mapping cellular landscapes through 2026, identifying molecular pathways through 2027, and comparing RA and OA disease mechanisms through 2028. Researchers also study potential blood biomarkers and OA subtypes. The total duration spans several years with ongoing assessments and molecular mapping.

Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis