Carpal Tunnel Syndrome

Carpal Tunnel Syndrome CTS causes numbness, tingling, pain, and weakness in the hand due to pressure on the median nerve at the wrist. This condition can affect daily activities, work, and quality of life. Researchers are studying whether taking an oral combination of alpha-lipoic acid, Vitamin E, and a Vitamin B complex can safely reduce CTS symptoms and improve hand function after surgery. This study is sponsored by Hospital Universiti Sains Malaysia and involves a single-blinded design where participants do not know which treatment they receive. Participants will be randomly assigned to one of two groups one receiving the oral supplement combination of alpha-lipoic acid, Vitamin E, and Vitamin B complex daily in capsule form, and the other receiving an oral Vitamin B complex as an active comparator. Both treatments are given once daily throughout the study. This approach aims to assess whether the supplement combination offers greater symptom relief and functional improvement compared to the comparator. During the study, symptoms such as pain and numbness will be measured using the Boston Carpal Tunnel Syndrome Questionnaire and a visual analog scale at the start, 12 weeks, and 24 weeks. Researchers will track changes in these scores to evaluate the treatments. Participant safety and side effects will be monitored, and the total study duration includes follow-up assessments to observe improvements and functional outcomes.

Carpal Tunnel Syndrome is a common condition that causes symptoms like tingling, pain, numbness, and weakness. Surgery called carpal tunnel release is the most effective treatment. This research compares two types of sutures used to close wounds after surgery absorbable and non-absorbable to see if one type affects the chance of wound infection. The study is a randomized controlled trial investigating how sutures influence infections after surgery. Participants will receive carpal tunnel release surgery where the flexor retinaculum is cut to relieve pressure. After surgery, wounds will be closed using either absorbable sutures Vicryl rapide or Safil quick or non-absorbable sutures Ethilon or Flexocrin. Both suture types are commonly used, but this study aims to find if one leads to fewer infections. The trial does not use masking, and participants are randomly assigned to one of the two suture groups. During the study, researchers will assess wound healing using the ASEPSIS wound score between 10 and 14 days after surgery. Patients will also record their pain using a Numeric Rating Scale for up to three weeks after surgery. Use of antibiotics, hand therapy, and any extra doctor visits will be recorded. The study is sponsored by Gelre Hospitals and includes adult participants aged 18 and older. Participation may last several weeks for follow-up and assessments.

Carpal tunnel syndrome CTS is a common nerve compression disorder affecting the wrist, caused by pressure on the median nerve within the carpal tunnel. Researchers are evaluating the use of ultrasound US and nerve conduction studies NCS as tools to help diagnose CTS, plan treatment, and monitor patients over time. This study focuses on how ultrasound can assist in understanding nerve changes and anatomical variations related to CTS. Participants will undergo high-resolution, real-time ultrasound imaging of both wrists using a 12 MHz linear array transducer. The ultrasound examinations will take place before surgery and again three months after surgery. This imaging approach aims to measure various nerve parameters such as size, blood flow, and movement, offering a non-invasive and quick method to support diagnosis and follow-up. During the study, patients will receive ultrasound assessments at specified times and clinical evaluations for CTS. Researchers will measure the sensitivity of ultrasound in diagnosing CTS during surgery. The study involves monitoring changes in the median nerve and surrounding structures to help improve diagnosis and management. Participation includes imaging visits and clinical follow-up over a period encompassing pre- and post-surgical assessments.

Researchers are studying patients with subacute stroke to evaluate the additional effects of kinesio taping combined with conventional physical therapy on upper limb function, range of motion, and spasticity. This randomized control trial aims to determine whether adding kinesio taping provides significant improvements compared to physical therapy alone. The study is conducted in rehabilitation settings and includes adults aged 40 to 65 years with a history of diagnosed stroke and moderate spasticity. Participants are divided into two groups. The experimental group receives kinesio taping three times per week along with physical therapy exercises including passive and active range of motion ROM, PNF stretching, D1 flexion and extension movements, and resistance training with a medium resistance band from weeks 3 to 6. The control group receives the same physical therapy regimen but without kinesio taping. Treatments last 30 minutes on alternate days over six weeks. During the study, participants upper limb spasticity and function are assessed at baseline, week 3, and week 6 using the Modified Ashworth Scale and the Wolf Motor Function Test. Range of motion is measured with a goniometer for shoulder, elbow, and wrist joints. Data collection includes demographic information and questionnaires. The study monitors outcomes throughout the six-week treatment period to analyze differences between groups.

Researchers are studying pain management methods for patients undergoing shoulder surgery, a common orthopedic procedure often linked with moderate to severe pain after surgery. The study compares two nerve block techniques the standard interscalene brachial plexus block, which can cause breathing difficulties due to unintended nerve effects, and a newer diaphragm-sparing method combining suprascapular and axillary nerve blocks. The goal is to assess pain relief and preserve respiratory function during recovery. Participants will receive one of two ultrasound-guided nerve block procedures before surgery. One group will have an interscalene block with 10 mL of 0.5% bupivacaine injected near the C5 and C6 nerve roots. The other group will receive a combination of suprascapular and axillary nerve blocks, each with 5 mL of 0.5% bupivacaine injected around specific nerves near the shoulder. Both procedures are designed to provide pain relief while minimizing breathing complications. During the study, participants pain intensity at rest and movement will be measured up to 24 hours after surgery, along with total opioid consumption. Respiratory function will be monitored by measuring diaphragmatic movement and lung volumes before and after the nerve blocks and throughout the perioperative period. The study includes adult patients aged 18 to 65 scheduled for elective arthroscopic shoulder surgery, with assessments focused on pain control and breathing safety.

Carpal tunnel syndrome is a common condition caused by nerve compression at the wrist, leading to symptoms like numbness, tingling, pain, weakness, and difficulty with daily activities. Researchers are studying how clinical severity relates to ultrasound results, nerve conduction tests, hand function, and symptom severity. This study aims to better understand the connection between these factors in adults with carpal tunnel syndrome. Participants will undergo a one-time diagnostic assessment during a single study visit. This includes measuring the median nerve cross-sectional area using ultrasound, performing nerve conduction studies, assessing hand grip strength with a dynamometer, measuring pressure pain threshold using a digital algometer, and completing the Boston Carpal Tunnel Questionnaire. No treatments will be given as part of this study. During the study visit, participants will complete all assessments and questionnaires to evaluate nerve and hand function and symptom severity. Researchers will analyze these measurements to understand their relationships. The primary outcome is the median nerve cross-sectional area measured by ultrasound. Secondary outcomes include symptom severity and function scores, grip strength, and pain threshold. The total participation involves only this single visit.

Researchers are investigating upper-extremity proprioception impairment in patients experiencing radicular neuropathic symptoms caused by cervical disc herniation. This study focuses on the specific subgroup of cervical radiculopathy, which has not been systematically examined before, aiming to better understand the relationship between proprioceptive deficits and clinical outcomes such as pain and functional status. The study compares patients aged 18 to 65 years with cervical radiculopathy to a healthy control group matched by age, sex, and body mass index. Proprioception is assessed using the PRO-Reach method, which measures multisensory spatial representation of the entire upper limb through multiplanar and multi-joint evaluations without the need for computerized or robotic devices. Participants undergo baseline assessments including the Upper Limb Proprioception Reaching Test PRO-Reach, pain rating scales Numeric Rating Scale and DN-4 Questionnaire, quality of life evaluation SHORT FORM-12, handgrip strength testing, and disability questionnaires Quick Disabilities of the Arm, Shoulder and Hand Questionnaire. These measures help researchers evaluate sensory-motor function and its impact. The study involves healthy volunteers and patients, with data collection focused on initial measurements before any treatments, and participation is expected to last during the baseline assessment period.

Researchers are evaluating the possible nerve damage that may occur after radial artery catheterization CAG or percutaneous coronary intervention PCI in patients with ischemic heart disease. This prospective study aims to assess whether accessing the radial artery increases the risk of nerve injury, particularly affecting the median nerve at the carpal tunnel or the ulnar nerve at Guyons canal. The study is conducted by Aarhus University Hospital Skejby and focuses on sensory and motor nerve function in the hands. Participants scheduled for radial CAG or PCI will have their sensory and motor nerve functions tested in both wrists and hands before the procedure. The study groups include patients with neurophysiological measurements taken on the same hand as the intervention ipsilateral and those measured on the opposite hand contralateral. Patients will complete questionnaires about hand and arm symptoms, and their ability to perform certain activities will be assessed before and one month after the procedure using tools such as the Katz chart. During the study, participants will undergo neurophysiological nerve measurements lasting about one hour before and one month after the procedure. Researchers will also evaluate the severity of hand symptoms and dysfunction through short questionnaires. This study helps monitor hand function changes over time and aims to identify any increased nerve damage related to radial artery interventions. The total participation involves initial testing, the procedure, and follow-up assessments approximately one month later.

This research aims to study patients who have undergone surgery for carpal tunnel syndrome CTS at lesund Hospital to identify the presence of ATTR amyloidosis through biopsy. The study focuses on patients with biopsy-confirmed ATTR amyloidosis, assessing whether they have cardiac amyloidosis and monitoring them closely over a long term. The study is observational and plans to follow participants for up to 10 years to understand the frequency of ATTR in CTS and cardiac involvement. Patients with biopsy-proven ATTR amyloidosis will undergo standard examinations recommended by guidelines, including 99mTcDPD SPECT CT, echocardiography, ECG, Holter monitoring, genetic testing for variant and wild type ATTR, laboratory tests, and CMRI when indicated. Light chain disease will be excluded. All patients will be monitored at least annually following established guidelines, and those developing cardiac amyloidosis will receive standard treatments approved by Norwegian authorities. Participants will be followed clinically and with echocardiography yearly for at least 10 years. Assessments include imaging, genetic testing, and laboratory evaluations to track disease progression and cardiac involvement. The primary outcome measures are the frequency of ATTR in CTS within 2 years and cardiac involvement in patients with biopsy-confirmed ATTR over 10 years. This extended follow-up aims to provide comprehensive data on the long-term impact of ATTR amyloidosis in this selected population.

Researchers are evaluating how the combined use of transcranial direct current stimulation tDCS and action observation therapy AOT may help improve hand motor recovery in people who have had a stroke. This study focuses on understanding the brain mechanisms involved when these two therapies are used together, as both have shown promise separately for stroke rehabilitation. The trial is a randomised controlled study involving 60 participants with chronic stroke from Sabah, Malaysia. Participants will be randomly assigned to one of three groups one group will receive active anodal tDCS with AOT, another will receive sham placebo tDCS with AOT, and the third will receive active tDCS alone. The treatment involves 10 sessions over two weeks in a clinic, where tDCS is applied for 20 minutes and AOT or control videos are watched for 30 minutes during each session. After the clinic phase, participants will continue home-based AOT or control video practice for 30 minutes a day, five days a week, for eight weeks. During the 10-week study, participants will attend outpatient sessions monitored by a physiotherapist to ensure proper participation and will be assessed at baseline, after two weeks, and at the end of 10 weeks. Researchers will measure changes in brain motor pathways using motor evoked potentials MEPs and evaluate clinical hand function using standard tests. Participant activity levels will be tracked using a perceived exertion scale, and safety and compliance will be closely monitored throughout the study.