Actively Recruiting
Effect of Oral Alpha-Lipoic Acid, Vitamin E, and Vitamin B Combination on Symptoms and Function in Carpal Tunnel Syndrome Following Carpal Tunnel Surgery
Led by Hospital Universiti Sains Malaysia · Updated on 2026-04-23
84
Participants Needed
1
Research Sites
7 weeks
Total Duration
On this page
Sponsors
H
Hospital Universiti Sains Malaysia
Lead Sponsor
B
BREGO Life Sciences Sdn Bhd
Collaborating Sponsor
AI-Summary
What this Trial Is About
Carpal Tunnel Syndrome (CTS) causes numbness, tingling, pain, and weakness in the hand due to pressure on the median nerve at the wrist. This condition can affect daily activities, work, and quality of life. Researchers are studying whether taking an oral combination of alpha-lipoic acid, Vitamin E, and a Vitamin B complex can safely reduce CTS symptoms and improve hand function after surgery. This study is sponsored by Hospital Universiti Sains Malaysia and involves a single-blinded design where participants do not know which treatment they receive. Participants will be randomly assigned to one of two groups: one receiving the oral supplement combination of alpha-lipoic acid, Vitamin E, and Vitamin B complex daily in capsule form, and the other receiving an oral Vitamin B complex as an active comparator. Both treatments are given once daily throughout the study. This approach aims to assess whether the supplement combination offers greater symptom relief and functional improvement compared to the comparator. During the study, symptoms such as pain and numbness will be measured using the Boston Carpal Tunnel Syndrome Questionnaire and a visual analog scale at the start, 12 weeks, and 24 weeks. Researchers will track changes in these scores to evaluate the treatments. Participant safety and side effects will be monitored, and the total study duration includes follow-up assessments to observe improvements and functional outcomes.
CONDITIONS
Brief Title
A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age more than 18 years old
- Symptoms and physical examination consistent with Carpal Tunnel Syndrome
- Scheduled for Carpal Tunnel release surgery
You will not qualify if you...
- Pregnant or breast-feeding women
- History of trauma in the dominant hand
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 weeks
Participants take an oral supplement daily after Carpal Tunnel release surgery to support nerve health and improve recovery.
Baseline visit and follow-up visits at 12 and 24 weeks
Trial Site Locations
Total: 1 location
1
Hospital Pakar Universiti Sains Malaysia
Kubang Kerian, Kelantan, Malaysia, 16150
Actively Recruiting
Research Team
N
Nurhakim Bin Ibrahim, MBBCH
A
ASSOCIATE PROFESSOR ABDUL NAWFAR BIN SADAGATULLAH
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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