Continuous Glucose Monitoring (CGM)

Researchers are evaluating the effect of Bragg Apple Cider Vinegar (ACV) liquid on blood sugar levels after eating carbohydrates in healthy adults aged 20 to 50 years. The main goal is to see if there is a difference in blood glucose levels measured over 120 minutes after consuming ACV compared to a placebo. This controlled clinical trial uses a randomized, single-blind, cross-over design to study this question. Participants will consume either one tablespoon of Bragg ACV liquid or four ounces of water as a placebo following a standardized carbohydrate load. The trial involves two study arms where participants receive both treatments at different times. Blood samples will be taken to measure glucose, insulin, and other markers over a two-hour period after intake. The study is sponsored by Bragg Live Food Products and is scheduled to run from August 2025 to March 2026. During the study, participants will undergo blood draws at multiple time points up to 120 minutes post-consumption. Researchers will track blood glucose and insulin levels to assess the impact of ACV versus placebo. Participants will be asked to maintain stable lifestyle habits and comply with dietary guidelines before clinic visits. Safety and adherence will be monitored throughout the study, which involves healthy volunteers without serious medical conditions. Total participation time varies based on study visits.

Researchers are evaluating the accuracy and safety of the new Syai Tag system for continuous glucose monitoring in patients admitted to intensive internal care. With nearly 150,000 people in Slovenia living with diabetes, monitoring blood sugar levels closely is essential to prevent complications. This study involves patients in the intensive care unit who require blood sugar monitoring during their stay. Participants will have two small sensors placed on each upper arm to continuously measure blood sugar levels using the Syai Tag system, though these readings will not be visible to medical staff. At the same time, healthcare professionals will carry out routine blood sugar measurements. The study compares the accuracy of the continuous glucose monitoring system to standard blood sugar tests over the duration of the ICU stay, up to 14 days. During the study, researchers will monitor sensor uptime and compare glucose readings from the Syai Tag system to arterial blood gas measurements. They will also evaluate the impact of noradrenaline on measurement accuracy and the lifespan of the sensors in ICU conditions. The procedure is safe and painless, and patients will continue to receive the usual high-quality care throughout their participation.

Increasing heat exposure caused by climate change is affecting communities worldwide, especially those living in poor housing conditions such as informal settlements and low-income households. This research aims to study the impact of applying sunlight-reflecting cool roof coatings on indoor temperatures and overall health. The trial is a global, multi-center, cluster-randomized controlled study conducted in five urban climate hotspots across Africa, Asia, Latin America, and Oceania, where heat exposure and vulnerable housing conditions pose significant health risks. The study compares households that receive a cool roof coating, which reflects sunlight and reduces indoor heat, with those that keep their original roofs. The cool roof coating works by reflecting ultraviolet and visible sunlight and radiating absorbed heat, thus lowering indoor temperatures and energy use. The trial will run over a 12-month period, including the hottest months of the year, to measure the effects on health, indoor environment, and economic outcomes. Participants will undergo repeated measurements including resting heart rate, blood glucose control, depression symptoms, and various health and environmental factors over the course of the study. Data will be collected at baseline and multiple times during the hottest months and alternate months. Researchers will monitor indoor air temperature, humidity, heat index, and household energy use continuously. The study seeks to provide evidence on whether cool roofs can improve physical, mental, and social wellbeing in vulnerable populations facing extreme heat.

This research aims to evaluate the effects of Hass Avocados on blood sugar control in adults with Type 2 diabetes. The study investigates whether eating Hass Avocados daily can reduce fasting blood sugar levels compared to consuming an equal calorie amount of other fruits. The trial is randomized and double-blind to carefully assess these effects under controlled conditions. Participants will be randomly assigned to one of two groups: one group will consume one Hass Avocado daily (about 240 calories per day), and the other group will receive other fruits matched for energy and form. This crossover design allows each participant to try both diets during the study period, helping to compare their impacts on blood sugar. During the study, participants will undergo blood tests at the start and after 5 weeks to measure fasting blood glucose, insulin, fructosamine, and glycated albumin levels. Researchers will monitor adherence to the diet and safety throughout the trial. The total participation spans at least 5 weeks per diet phase, with close monitoring of metabolic markers to understand how avocado consumption influences glycemic control.

Researchers are investigating how often and for how long people should interrupt prolonged periods of sitting to improve heart and metabolic health. This Phase 1 study aims to find the smallest effective combination of break frequency and duration that can lower blood pressure and glucose levels. The trial also seeks to identify the highest tolerable break levels without causing physical or emotional distress, helping guide future public health recommendations. Participants will complete two 9-hour lab visits where they either remain seated continuously or take walking breaks on a treadmill at different frequencies and durations. The walking speeds are fixed, and breaks vary from every 30 to 120 minutes and last between 1 and 10 minutes. All participants will follow a controlled diet for two days before and during the visits. The study uses an adaptive randomization method to test 25 different break patterns efficiently. During each visit, participants wear heart rate and blood pressure monitors while researchers measure blood pressure and glucose at multiple times. They will also assess how well participants tolerate the breaks by checking fatigue, mood, safety, and ability to complete the protocol. The study involves 324 adults who will each experience both conditions in randomized order. The findings will help determine effective and acceptable sedentary break guidelines for cardiovascular health.

Researchers are evaluating the effects and safety of green tea extract on blood sugar regulation. This 12-week study uses a randomized, double-blind, placebo-controlled design to compare green tea extract tablets with placebo tablets in adults aged 19 to 64 years who have elevated fasting blood glucose levels. The study aims to see if green tea extract can reduce blood glucose levels and affect related metabolic indicators. Participants will be randomly assigned to take either three green tea extract tablets or three placebo tablets once daily for 12 weeks. The study groups receive their assigned tablets orally each day during this period. The design ensures that neither participants nor researchers know who receives the active supplement or placebo until the study concludes. During the study, participants will have their fasting glucose levels measured at the start and after 12 weeks. Researchers will also assess lipid metabolism markers, oral glucose tolerance tests, blood biomarkers, and waist circumference at these times. This includes safety monitoring and evaluation of any changes in these health measures over the study period. The total participation time is 12 weeks.

Knee osteoarthritis (OA) is a common and disabling joint condition, especially in older adults, causing pain and limited function. This research compares two types of prolotherapy injections using a sugar solution called dextrose to manage knee OA. The study aims to find out if targeting injections based on MRI-detected knee damage is more effective than standard intra-articular injections that go directly into the knee joint. Participants will be randomly assigned to one of two groups. One group receives ultrasound-guided injections of 5 ml 20% dextrose into the knee joint at weeks 0, 2, and 4, plus physical therapy three times weekly for 4 weeks. The other group undergoes MRI scans and detailed knee exams, then receives ultrasound-guided injections of 20% dextrose around MRI-identified lesion sites with varying needle sizes as needed, also at weeks 0, 2, and 4, along with the same physical therapy. During the study, participants will be assessed at baseline, 1.5, 3, and 6 months after treatment starts. Measures include the Western Ontario McMaster University Osteoarthritis Index (WOMAC) for pain and function, pain visual scales, quality of life surveys, and mobility tests. Researchers will monitor treatment effects and safety throughout. The total study duration for each participant spans at least 6 months to evaluate lasting benefits.

Researchers are evaluating the use of continuous glucose monitors (CGM) in patients in intensive care units (ICU) who have undergone major surgeries such as pancreas surgery, liver transplantation, or simultaneous pancreas and kidney transplantation, including those with diabetes mellitus. The study aims to determine if CGM helps maintain blood glucose within the recommended target range and to compare the accuracy of CGM sensors with standard blood glucose measurement methods. This non-commercial, randomized, open-label study is conducted to address the challenges of glucose control in ICU patients and reduce the burden on nursing staff. Participants will be randomized into two groups: one group will use an active CGM device (Dexcom G6) to guide insulin therapy, while the control group will receive standard care with blinded CGM monitoring without influencing treatment. Continuous glucose monitoring begins after surgery to avoid interference during procedures, and insulin doses will be adjusted according to the standard ICU protocol. Each surgical patient group will be randomized and analyzed independently. During the approximately 5 to 7 days in the postoperative ICU, participants will have their glucose levels continuously monitored and insulin doses recorded. Researchers will measure the time spent in the target glucose range, episodes of high or low blood sugar, glycemic variability, surgical and infectious complications, and duration of hospital stay. Blood glucose will also be measured using standard biochemistry methods. This comprehensive monitoring aims to compare the performance and benefits of CGM in maintaining glucose control during critical postoperative care.

Researchers are conducting two studies to explore how dairy cheese and its dairy-free alternative affect feelings of fullness and blood sugar levels after eating. These studies involve healthy young adults and aim to better understand the health properties of both types of cheese. Secondary aspects include how the foods taste, their impact on energy and fatigue, digestion comfort, and overall food intake. Participants will try foods containing dairy cheese, a vegan cheese substitute, and a control food in a randomized order. The studies will monitor blood glucose, insulin levels, satiety, and food intake over 120 minutes after consumption. Additional measurements include energy and fatigue, gastrointestinal comfort, diet-induced thermogenesis, and sensory characteristics at the start and end of the test period. During the study, participants will undergo assessments of blood sugar and insulin at multiple time points, along with evaluations of how full they feel and how much they eat. Researchers will also collect feedback on energy levels, digestive comfort, and the sensory qualities of the foods. The studies are designed to include healthy volunteers aged 19 to 35 and will provide insights over the short 2-hour post-meal period.

This research focuses on patients undergoing laparoscopic colorectal surgery for various conditions. It aims to evaluate heart rate variability (HRV) parameters, such as RMSSD, before and after surgery to understand how surgical effects and possible complications impact these measurements and relate to specific adverse outcomes. Participants receive standard colorectal surgery followed by monitoring using the PulseOn device to measure HRV after the operation. The study specifically examines changes in HRV within three days post-surgery to assess recovery and complications. During the study, participants' HRV is tracked before and after surgery, with data collected via the PulseOn device. Researchers monitor HRV changes and complications to evaluate recovery quality. The total participation involves preoperative and postoperative assessments focused on physiological monitoring within the first few days after surgery.