Continuous Glucose Monitoring (CGM)

Researchers are investigating the effects of replacing traditional non-diet soda with a prebiotic soda called OLIPOP on blood sugar control in adults who regularly consume traditional sodas and have glucose regulation issues. This study focuses on adults aged 30 to 70 with glucose dysregulation to see how this change impacts markers related to blood sugar control over time. Participants will be randomly assigned to one of two groups one group will replace their usual soda intake with 2 cans per day of OLIPOP prebiotic soda, providing 12 grams of dietary fiber daily, while the other group will continue their normal consumption of traditional non-diet soda at 2 to 3 servings per day. The study lasts for 8 weeks, during which the effects on fasting plasma glucose and other markers of metabolic health will be assessed. Throughout the study, participants will be monitored for changes in blood sugar control using fasting plasma glucose tests, as well as assessments of long-term glycemic control and insulin sensitivity. Researchers will also track participants adherence to their assigned soda consumption and lifestyle habits. The total study duration for each participant is 8 weeks, with measurements taken at the start and end of this period to evaluate the impact of the soda replacement.

Researchers are evaluating the accuracy and safety of the new Syai Tag system for continuous glucose monitoring in patients admitted to intensive internal care. With nearly 150,000 people in Slovenia living with diabetes, monitoring blood sugar levels closely is essential to prevent complications. This study involves patients in the intensive care unit who require blood sugar monitoring during their stay. Participants will have two small sensors placed on each upper arm to continuously measure blood sugar levels using the Syai Tag system, though these readings will not be visible to medical staff. At the same time, healthcare professionals will carry out routine blood sugar measurements. The study compares the accuracy of the continuous glucose monitoring system to standard blood sugar tests over the duration of the ICU stay, up to 14 days. During the study, researchers will monitor sensor uptime and compare glucose readings from the Syai Tag system to arterial blood gas measurements. They will also evaluate the impact of noradrenaline on measurement accuracy and the lifespan of the sensors in ICU conditions. The procedure is safe and painless, and patients will continue to receive the usual high-quality care throughout their participation.

Increasing heat exposure caused by climate change is affecting communities worldwide, especially those living in poor housing conditions such as informal settlements and low-income households. This research aims to study the impact of applying sunlight-reflecting cool roof coatings on indoor temperatures and overall health. The trial is a global, multi-center, cluster-randomized controlled study conducted in five urban climate hotspots across Africa, Asia, Latin America, and Oceania, where heat exposure and vulnerable housing conditions pose significant health risks. The study compares households that receive a cool roof coating, which reflects sunlight and reduces indoor heat, with those that keep their original roofs. The cool roof coating works by reflecting ultraviolet and visible sunlight and radiating absorbed heat, thus lowering indoor temperatures and energy use. The trial will run over a 12-month period, including the hottest months of the year, to measure the effects on health, indoor environment, and economic outcomes. Participants will undergo repeated measurements including resting heart rate, blood glucose control, depression symptoms, and various health and environmental factors over the course of the study. Data will be collected at baseline and multiple times during the hottest months and alternate months. Researchers will monitor indoor air temperature, humidity, heat index, and household energy use continuously. The study seeks to provide evidence on whether cool roofs can improve physical, mental, and social wellbeing in vulnerable populations facing extreme heat.

This research aims to evaluate the effects of Hass Avocados on blood sugar control in adults with Type 2 diabetes. The study investigates whether eating Hass Avocados daily can reduce fasting blood sugar levels compared to consuming an equal calorie amount of other fruits. The trial is randomized and double-blind to carefully assess these effects under controlled conditions. Participants will be randomly assigned to one of two groups one group will consume one Hass Avocado daily about 240 calories per day, and the other group will receive other fruits matched for energy and form. This crossover design allows each participant to try both diets during the study period, helping to compare their impacts on blood sugar. During the study, participants will undergo blood tests at the start and after 5 weeks to measure fasting blood glucose, insulin, fructosamine, and glycated albumin levels. Researchers will monitor adherence to the diet and safety throughout the trial. The total participation spans at least 5 weeks per diet phase, with close monitoring of metabolic markers to understand how avocado consumption influences glycemic control.

Researchers are investigating how often and for how long people should interrupt prolonged periods of sitting to improve heart and metabolic health. This Phase 1 study aims to find the smallest effective combination of break frequency and duration that can lower blood pressure and glucose levels. The trial also seeks to identify the highest tolerable break levels without causing physical or emotional distress, helping guide future public health recommendations. Participants will complete two 9-hour lab visits where they either remain seated continuously or take walking breaks on a treadmill at different frequencies and durations. The walking speeds are fixed, and breaks vary from every 30 to 120 minutes and last between 1 and 10 minutes. All participants will follow a controlled diet for two days before and during the visits. The study uses an adaptive randomization method to test 25 different break patterns efficiently. During each visit, participants wear heart rate and blood pressure monitors while researchers measure blood pressure and glucose at multiple times. They will also assess how well participants tolerate the breaks by checking fatigue, mood, safety, and ability to complete the protocol. The study involves 324 adults who will each experience both conditions in randomized order. The findings will help determine effective and acceptable sedentary break guidelines for cardiovascular health.

Researchers are evaluating the effects and safety of green tea extract on blood sugar regulation. This 12-week study uses a randomized, double-blind, placebo-controlled design to compare green tea extract tablets with placebo tablets in adults aged 19 to 64 years who have elevated fasting blood glucose levels. The study aims to see if green tea extract can reduce blood glucose levels and affect related metabolic indicators. Participants will be randomly assigned to take either three green tea extract tablets or three placebo tablets once daily for 12 weeks. The study groups receive their assigned tablets orally each day during this period. The design ensures that neither participants nor researchers know who receives the active supplement or placebo until the study concludes. During the study, participants will have their fasting glucose levels measured at the start and after 12 weeks. Researchers will also assess lipid metabolism markers, oral glucose tolerance tests, blood biomarkers, and waist circumference at these times. This includes safety monitoring and evaluation of any changes in these health measures over the study period. The total participation time is 12 weeks.

Knee osteoarthritis OA is a common and disabling joint condition, especially in older adults, causing pain and limited function. This research compares two types of prolotherapy injections using a sugar solution called dextrose to manage knee OA. The study aims to find out if targeting injections based on MRI-detected knee damage is more effective than standard intra-articular injections that go directly into the knee joint. Participants will be randomly assigned to one of two groups. One group receives ultrasound-guided injections of 5 ml 20% dextrose into the knee joint at weeks 0, 2, and 4, plus physical therapy three times weekly for 4 weeks. The other group undergoes MRI scans and detailed knee exams, then receives ultrasound-guided injections of 20% dextrose around MRI-identified lesion sites with varying needle sizes as needed, also at weeks 0, 2, and 4, along with the same physical therapy. During the study, participants will be assessed at baseline, 1.5, 3, and 6 months after treatment starts. Measures include the Western Ontario McMaster University Osteoarthritis Index WOMAC for pain and function, pain visual scales, quality of life surveys, and mobility tests. Researchers will monitor treatment effects and safety throughout. The total study duration for each participant spans at least 6 months to evaluate lasting benefits.

Researchers are conducting two studies to explore how dairy cheese and its dairy-free alternative affect feelings of fullness and blood sugar levels after eating. These studies involve healthy young adults and aim to better understand the health properties of both types of cheese. Secondary aspects include how the foods taste, their impact on energy and fatigue, digestion comfort, and overall food intake. Participants will try foods containing dairy cheese, a vegan cheese substitute, and a control food in a randomized order. The studies will monitor blood glucose, insulin levels, satiety, and food intake over 120 minutes after consumption. Additional measurements include energy and fatigue, gastrointestinal comfort, diet-induced thermogenesis, and sensory characteristics at the start and end of the test period. During the study, participants will undergo assessments of blood sugar and insulin at multiple time points, along with evaluations of how full they feel and how much they eat. Researchers will also collect feedback on energy levels, digestive comfort, and the sensory qualities of the foods. The studies are designed to include healthy volunteers aged 19 to 35 and will provide insights over the short 2-hour post-meal period.

This research focuses on patients undergoing laparoscopic colorectal surgery for various conditions. It aims to evaluate heart rate variability HRV parameters, such as RMSSD, before and after surgery to understand how surgical effects and possible complications impact these measurements and relate to specific adverse outcomes. Participants receive standard colorectal surgery followed by monitoring using the PulseOn device to measure HRV after the operation. The study specifically examines changes in HRV within three days post-surgery to assess recovery and complications. During the study, participants HRV is tracked before and after surgery, with data collected via the PulseOn device. Researchers monitor HRV changes and complications to evaluate recovery quality. The total participation involves preoperative and postoperative assessments focused on physiological monitoring within the first few days after surgery.

This research aims to find out if eating a small serving of almonds before meals can help control blood sugar levels in adults who show early signs of blood sugar regulation problems, which can lead to type 2 diabetes. The study investigates whether this dietary approach reduces the rise in blood sugar after eating and whether some people benefit more consistently than others. Participants will take part in two phases. The first phase involves a controlled setting where participants undergo mixed meal tolerance tests with and without eating almonds before meals. The second phase involves following a controlled diet at home for 10 days, sometimes including almonds before meals and sometimes not. The study uses several randomization sequences to compare responses with and without almond ingestion. During the study, participants will be monitored closely with blood sugar tests at various times before and after meals. Researchers will measure how almonds affect blood sugar spikes in both short-term tests and longer diet periods. The study also tracks individual differences in response to almonds and consistency between short-term and longer-term blood sugar control. The total study duration includes multiple test days and a 10-day home diet phase.