Hip Replacement / Arthroplasty

Researchers are evaluating the use of Synolis VA 80/160, a device containing hyaluronic acid and sorbitol, in adults with hip osteoarthritis. This study aims to assess the effectiveness and safety of this treatment over a 6-month period in patients experiencing symptoms related to this condition who have not responded well to standard pain relief treatments. The study is conducted independently across multiple centers. Participants will receive a single guided injection of Synolis VA 80/160 directly into the affected hip joint. The study monitors changes in hip function and pain using the Oxford Hip Score at various points including 3 and 6 months after injection. Additional evaluations include patient self-assessments of symptom evolution and tracking whether participants require hip prosthesis placement within 6 months. During the study, participants will undergo assessments at baseline and follow-up visits where their hip function and symptoms are measured using standard questionnaires. The main outcome is the evolution of the Oxford Hip Score after 6 months. Researchers will also monitor safety and any need for hip replacement surgery. Participants will be involved for the full 6-month study duration, with data collected to understand both short-term and longer-term effects of the treatment.

This research aims to compare myoelectric and bionic prosthetic hands to understand differences in upper limb function, body image, and user satisfaction among individuals with upper limb amputations. It focuses on answering whether the functional abilities differ between these two types of prosthetic devices used by people with amputations. The study is observational and involves adults aged 18 to 65 who regularly use prosthetic hands. Participants will either use advanced bionic prosthetic hands featuring multi-articulating structures and enhanced control systems designed to improve function and dexterity or myoelectric prosthetic hands controlled by muscle signals from the residual limb that provide basic powered hand movements. These groups allow comparison of the newer bionic technology against conventional myoelectric devices. During the study, participants will complete assessments including the Upper Limb Functional Index-15, Amputee Body Image Scale, and Orthotics and Prosthetics Users' Survey at baseline. These measures will help evaluate hand function, body image perception, and satisfaction with prosthetic use. The study is led by Gulhane School of Medicine and participation spans from November 2025 to March 2026, involving adults with unilateral upper limb amputation who have been using prostheses for at least six months.

Researchers are studying the long-term performance of the Mpact 3D Metal MonoCER cup used in total hip arthroplasty for patients under 75 years old. This observational study aims to assess how well the implant lasts and functions over a period of 10 years after the surgery. The study focuses on patients receiving this specific metal cup as part of their hip replacement. Participants will receive the Mpact 3D Metal cup as an acetabular shell device during their total hip arthroplasty surgery. The study follows standard treatment practices, and patients who choose not to participate will receive the same care. Follow-up visits are scheduled at 6 months, 1 year, 5 years, and 10 years after surgery to monitor outcomes. During these visits, researchers will check the implant's survivorship using Kaplan Meier analysis and assess device stability through radiological exams. They will also evaluate clinical outcomes using the Harris Hip score and monitor safety by collecting any adverse events up to 10 years after surgery. This comprehensive follow-up helps ensure detailed understanding of the device's long-term effects and performance.

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or Weil/Hohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing (10-15 kg) during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery: one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

This research aims to evaluate how different methods of reattaching the abductor muscles during proximal femur resection and reconstruction with an endoprosthesis affect patient function. The study focuses on patients treated at Duke University Medical Center by orthopedic oncology surgeons for conditions such as sarcoma and bone metastases. Researchers want to find out if directly attaching the abductors to the prosthesis leads to better functional outcomes and develop a simple way to assess this function using routine X-rays during follow-up visits. The study involves reviewing up to 300 patient records retrospectively to identify those who had a proximal femur replacement. From these, 50 patients will be consented: 25 who have upcoming clinic visits and 25 who are scheduled for surgery. The intervention under observation is the proximal femur replacement procedure with different abductor muscle repair techniques. There is no drug or placebo; instead, the focus is on surgical methods and outcomes after the procedure. Participants will be followed for up to 24 months after surgery to assess their recovery and function. This includes measuring function with the Musculoskeletal Tumor Society score and Harris Hip Score, tracking any implant-related complications, and performing gait analysis. Clinical visits will include plain radiographs to evaluate abductor muscle function. The study also monitors safety and adverse events during this period, providing a comprehensive view of patient outcomes after their proximal femur replacement.

This research aims to evaluate how well patients with various musculoskeletal conditions follow personalized home-based exercise programs prescribed by their physicians. It focuses on patients with degenerative, orthopedic, or neurological disorders undergoing rehabilitation. The study seeks to identify differences in adherence across these groups and explore factors such as demographics, clinical status, psychosocial elements, and physical function that might influence exercise compliance. Participants will receive customized home exercise programs designed by physical therapy and rehabilitation physicians based on their specific clinical needs. These exercises complement clinic-based treatments and are tailored to individual conditions within three subgroups: chronic degenerative disorders, post-operative orthopedic rehabilitation, and neurological rehabilitation following conditions like stroke or hemiplegia. The home programs will last six weeks, with clear instructions and printed materials provided to support correct performance. During the study, patients' adherence and clinical progress will be assessed at the beginning and end of the six-week program using standardized tools such as the Exercise Adherence Rating Scale, Beck Depression Index, Visual Analog Scale for pain, Barthel Index for daily living activities, Tampa Kinesiophobia Scale, and Health Assessment Questionnaire. Researchers will monitor mood, functional status, pain levels, and fear of movement to understand adherence patterns. The study will also evaluate patients' satisfaction and factors influencing their commitment to the home exercises, aiming to improve future rehabilitation strategies.

Researchers are evaluating the use of biocellular and cellular therapies derived from a person's own stem/stromal cells combined with platelet-rich plasma (PRP) to treat osteoarthritis (OA) and related musculoskeletal aging, pain, and degeneration. This study aims to explore minimally invasive, non-pharmaceutical treatments to relieve OA symptoms and improve joint function, addressing the limitations of traditional surgeries and medical management. The study tracks baseline health and monitors progress over time to understand treatment impact. The trial includes three treatment approaches: 1) guided biocellular therapy using tissue stromal vascular fraction (tSVF) plus PRP concentrate; 2) combined biocellular and cellular therapy with tSVF, PRP, and cellular stromal vascular fraction (cSVF); and 3) cSVF delivered intravenously suspended in sterile normal saline. Treatments involve harvesting stem cells and platelets, guided placement with ultrasound, and systemic infusion. Participants receive one or more treatments, with follow-up tracking to compare outcomes from single versus multiple sites or treatments. Participants will undergo regular assessments including imaging with ultrasound and radiography, pain scales, and joint function questionnaires at baseline, 1 month, 6 months, and up to 2 years post-treatment. Researchers monitor complications, pain changes, and structural joint improvements while participants report any unexpected adverse events. The trial includes long-term follow-up to assess safety and effectiveness of these regenerative therapies for OA and connective tissue degeneration.

The American Joint Replacement Registry (AJRR) is a not-for-profit organization focused on collecting data and improving quality for total hip and knee replacement surgeries across the United States. This observational study collects information to support quality improvement efforts involving hospitals, surgeons, insurers, and device manufacturers. The registry is supported by several professional societies including the American Academy of Orthopaedic Surgeons and the American Association of Hip and Knee Surgeons. Participants are individuals undergoing total joint arthroplasty. Data is collected observationally without specific treatment assignments or interventions. The registry gathers information from various sources to monitor outcomes and quality measures related to joint replacement surgeries. Participants' health-related quality of life will be assessed at 12 months, along with specific measures like the Hip disability and Osteoarthritis Outcome Score - Joint Replacement (HOOS, JR). The study collects ongoing data to support improvements in joint replacement care while allowing participants to continue with their usual medical care. Participation duration varies depending on individual surgery and follow-up schedules.

Researchers are studying the use of My Connect Post-Op Software as a communication tool to support recovery after total hip or knee replacement surgery. This open-label, multi-center observational study will evaluate how effectively the software guides patients through their recovery, identifies potential complications, and provides recommendations based on structured conversations. The study includes adult orthopedic patients undergoing elective joint replacement surgeries who meet eligibility requirements. Participants will be trained on using the My Connect Post-Op device before their surgery during an in-office visit. After discharge, they will engage with the software daily for 30 days, responding to prompts and questions about their recovery. The software collects data on pain, sleep, activity, medication use, and diet, using tools like the GRASP device and smartphone slider for pain reporting. A control group will be formed by reviewing records of past patients who underwent similar surgeries. The study also includes a provider dashboard for managing patients and conducting real-time chats. During the 30-day study period, researchers will collect detailed conversation logs and monitor how the software supports clinical decision-making. Patient and provider satisfaction will be assessed periodically. Data on the software's chat responsiveness, clarity, and usability will also be gathered. The study aims to ensure the communication tool covers a wide range of clinical scenarios and supports patient recovery effectively.

The trial investigates pain management techniques after total hip arthroplasty (THA), a common surgery for older adults to relieve hip pain and improve joint function. Researchers are comparing two nerve block methods, the Quadro-Iliac Plane Block (QIPB) and the Erector Spinae Plane Block (ESPB), to assess their effectiveness in reducing postoperative pain and opioid use. The study addresses concerns about opioid side effects such as nausea and dependence. Participants receive either the QIPB or ESPB, each involving an injection of 20ml of 0.25% bupivacaine on the side of surgery. These blocks aim to numb nerves to control pain after surgery. The study is randomized and double-blind, meaning participants are assigned randomly to one of the two groups and neither participants nor researchers know the assignment during the trial. During the first 24 hours after surgery, participants are monitored for how long it takes before they need extra pain relief, the total amount of morphine used, their pain levels, quality of recovery, and any side effects. Various assessments track these outcomes to compare the two treatments. This comprehensive monitoring helps evaluate which block may better manage pain with fewer complications.