Osgood-Schlatter Disease

Researchers are evaluating post-operative management approaches after a modified Lapidus arthrodesis surgery for hallux valgus, with or without additional surgeries such as Akin or Weil/Hohmann procedures. The study aims to compare the effectiveness and safety of immediate full weight-bearing versus partial weight-bearing (10-15 kg) during rehabilitation. This randomized controlled trial explores a new rehabilitation method following foot surgery to improve recovery. Participants will be randomly assigned to one of two groups after surgery: one group will follow partial weight-bearing with a specialized VACOPASO shoe and use crutches along with antithrombotic medication for 6 weeks, while the other group will have immediate complete weight-bearing with the same shoe and medication for the same period. The surgical operation follows standard clinical practices for hallux valgus correction. During the study, healing progress will be monitored through standard X-rays at 6, 12, and 24 weeks to check bone healing, hardware fixation, and fracture alignment. Pain will be measured using a Visual Analogue Scale at the day of surgery and at follow-up visits. Quality of life and functional recovery will be assessed through established foot and ankle scoring systems at multiple time points. The main outcome is the subjective functional recovery measured by the Olerud and Molander Ankle Score at 6 weeks post-surgery.

Researchers are evaluating the effect of a student-led multimodal prehabilitation service called BoneFit for people preparing for total hip or knee replacement surgery. The study aims to improve physical and mental health, quality of life, and reduce hospital stay length, complications, and readmission rates for patients undergoing orthopedic surgery in the Hull region. This pilot feasibility study will compare BoneFit to usual care, as no prehabilitation service is currently offered locally. Participants in the BoneFit intervention group will receive a personalized care plan that includes exercise, nutrition, and psychological support tailored to their needs during the 8 weeks before surgery. A control group will receive usual care without intervention. The groups will be compared to assess the impact of the prehabilitation service. During the study, participants will undergo baseline tests and will be invited to repeat these assessments 3 months after surgery. Researchers will monitor recruitment, attendance, and acceptability over several years. They will also measure physical fitness, hospital length of stay, readmission rates, overall quality of life, and specific pain and function related to the knee or hip. The study will last up to 3 years, with ongoing follow-up assessments to evaluate outcomes.

This observational study is focused on collecting data about the performance of CERAMENT BONE VOID FILLER, a synthetic biphasic bone graft substitute, when used in typical medical practice for orthopedic disorders. The study is sponsored by BONESUPPORT AB and aims to gather information on device performance and patient outcomes to understand its use in real-world settings. Participants will receive CERAMENT BVF as part of their treatment at approved healthcare centers following the product's instructions for use. Data collection includes monitoring unexpected device performance, complaints, adverse events, and serious adverse events during surgery and continuing up to 18 months after treatment. Radiological assessments, pain scores, and quality of life evaluations will be conducted at intervals throughout the study. During the study, participants will undergo scheduled reviews at 6, 12, and 18 months to assess device-related outcomes and healing progress using imaging and questionnaires. Researchers will track safety events and gather patient-reported outcomes such as pain levels and quality of life. Participation involves following up with healthcare providers over this period to provide ongoing data for comprehensive evaluation of the device's performance.

This research evaluates the clinical and radiological outcomes in patients who have undergone total ankle replacement for advanced ankle osteoarthritis. The study aims to assess results achieved by surgeons who did not originally design the implant, addressing potential bias seen in prior studies where designers performed the surgeries. The goal is to compare these outcomes with those of ankle arthrodesis, considering improvements in surgical techniques and ankle biomechanics knowledge. Participants in the study have received total ankle arthroplasty using a third-generation ankle replacement device. Clinical assessments are performed before and after surgery, with a minimum follow-up of 12 months. These include the American Orthopedic Foot and Ankle (AOFAS) score, the Foot Function Index, and the visual analogue scale (VAS) for pain. Weightbearing ankle X-rays are taken before surgery and at the final follow-up, with independent review by an orthopedic surgeon. During the study, participants complete scheduled follow-up evaluations, questionnaires, and radiographic exams. Researchers measure implant survivorship over 10 years along with various ankle joint angles and functional scores. The study monitors clinical progress, radiological changes, and foot function to evaluate long-term outcomes of the ankle replacement procedure.

This research aims to evaluate the effects of cryoneurolysis, a minimally invasive procedure, on reducing shoulder and knee pain in adults recovering from acute neurological conditions such as stroke. Hemiplegic shoulder pain is a common complication after stroke, often interfering with rehabilitation and quality of life. The study also explores secondary goals like reducing pain medication use, improving independence, range of motion, and involving an interdisciplinary care team for better patient selection. Cryoneurolysis involves using a cold probe guided by ultrasound to target nerves responsible for pain and spasticity, causing a temporary disruption that allows nerve regeneration. This procedure is performed on patients with shoulder or knee pain due to stroke or osteoarthritis. The study includes adults who are candidates for cryoneurolysis as part of their standard care during inpatient rehabilitation or outpatient follow-up within 16 weeks of their neurological event. Participants will be assessed before the procedure and at 1 week, 1 month, and 4 months afterward. Measures include changes in pain, range of motion, muscle tone, grip strength, functional independence, and walking ability. Questionnaires and physical tests such as the 10-meter walk and timed up and go test will be used to monitor progress. The study involves regular follow-ups to evaluate the safety and effectiveness of cryoneurolysis in improving rehabilitation outcomes over several months.

Researchers are evaluating the best timing for rehabilitation after reverse total shoulder arthroplasty (rTSA) in patients aged 50 to 85 who have suffered proximal humerus fractures. This study aims to determine whether starting physical therapy early or delaying it affects shoulder motion, patient-reported outcomes, and postoperative complications. The goal is to improve recovery protocols for this patient group, as current practices vary widely. Participants will be randomly assigned to one of two groups: one begins physical therapy two weeks after surgery (early rehabilitation), and the other starts six weeks after surgery (delayed rehabilitation). Both groups will follow their assigned rehabilitation schedule postoperatively. The study includes in-person clinic visits and radiographic evaluations at six weeks, three months, and six months after surgery to monitor progress and safety. Throughout the study, participants will undergo range of motion measurements using a goniometer and complete patient-reported outcome assessments such as the American Shoulder Elbow Surgeons Shoulder Score and Constant score. Researchers will also review medical charts and radiographs to track any postoperative complications. The total follow-up period spans six months, allowing for detailed monitoring of recovery and functional outcomes.

Researchers are evaluating the effect of a podcast about constipation on patients undergoing planned orthopedic surgeries such as knee, hip, shoulder, and back operations. This randomized controlled trial aims to see if the podcast can reduce the number of patients experiencing constipation before and after surgery. The study includes adults 18 years or older who can use digital devices and do not have certain gastrointestinal conditions or severe hearing or cognitive impairments. Participants will be randomly assigned to either a control group or an intervention group. Both groups receive standard preoperative information, but the intervention group also gets access to a 30-minute podcast featuring expert explanations and patient experiences related to constipation around surgery. The podcast is accessible throughout the study period. Data will be collected through online questionnaires at four points: after the preoperative consultation, shortly before surgery, one week after surgery, and four weeks after surgery. During the study, participants will complete questionnaires assessing constipation using the ROME IV Diagnostic Criteria and quality of life related to constipation via the PAC-QOL tool. Additional information will be gathered about laxative use, educational and living situations, and healthcare contacts from patient records. The researchers will monitor hospitalizations, outpatient visits, and general practitioner contacts up to six months after surgery to evaluate the overall impact. Participation lasts from pre-surgery consultation through four weeks after surgery, with some data extending to six months post-surgery.

This research aims to study dynamic asymmetries in the lower limbs of adults with unilateral motor impairments caused by conditions like post-stroke hemiparesis, Parkinson's disease, multiple sclerosis, unilateral amputation, or orthopedic surgeries. It evaluates how walking on a split-belt treadmill, where each leg moves at a different speed, affects gait patterns and neural control of walking. The study seeks to clarify the potential of this split gait as a rehabilitation tool by investigating spatial and dynamic asymmetries and their effects on body movement. Participants will perform walking tests on a split-belt treadmill with belts moving at different speeds in a specific sequence: a baseline phase with increasing speed, a short habituation phase, an adaptation phase where one leg walks faster than the other for six minutes, and a post-adaptation phase where belt speeds are equal again for six minutes. After one week, participants repeat the protocol with the affected limb on the faster belt. The treadmill is equipped with force sensors, and participants walk freely without support. During the study, researchers will assess ankle joint power, step length, single and double stance times, and center of mass motion through two assessments spaced a week apart. Participants will be informed verbally before belt speed changes. The study involves adults aged 18 to 70 who can walk at least 20 meters unaided and understand instructions. The total participation includes multiple walking sessions and repeated assessments to monitor gait adaptation and symmetry changes.

Researchers are investigating painful inflammation in the patellofemoral joint affected by osteoarthritis (PFJ OA) using a combined imaging method called [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI). This method aims to detect pain-related inflammation by measuring glucose usage in tissues and detailed anatomy of the knee. The study focuses on distinguishing normal metabolic activity caused by weight-bearing from abnormal inflammation linked to pain in patients with PFJ OA compared to people without symptoms. The study involves two main parts. First, participants will undergo PET/MRI scans of the unloaded knee to measure FDG uptake in painful areas and compare these between PFJ OA patients and matched healthy controls. Then, participants will have a second PET/MRI scan while the knee is loaded with 25% of body weight using a custom device to assess changes in inflammation under stress. Biomechanical measurements during physical tests like single-leg squats will also be collected to analyze their relationship with imaging results. Participants will be adults able to perform 25 single-leg squats and without recent traumatic knee injuries or contraindications to MRI or PET. They will complete imaging sessions in both unloaded and loaded knee states, followed by physical performance tests. Researchers will measure maximum standardized uptake values (SUVmax) of FDG in knee tissues before and after loading, and evaluate pain scores during squats. This approach aims to improve understanding of inflammation and pain in PFJ OA, supporting development of better diagnostic and treatment methods. The study is expected to continue until February 2028.

Researchers are evaluating treatments for patients experiencing atraumatic knee pain without a large knee effusion visible on x-ray in the emergency department. The study aims to compare the effects of a genicular nerve block with standard pain relief methods to understand which approach better manages knee pain. This randomized controlled trial is sponsored by the University of Pennsylvania and focuses on adult patients with moderate to severe knee pain who have undergone knee x-rays in the emergency setting. Participants will be randomly assigned to one of two groups. One group will receive an ultrasound-guided genicular nerve block using bupivacaine 0.5% and dexamethasone dosed by ideal body weight. The other group will receive standard care pain relief, which may include acetaminophen, NSAIDs, or opioids. There are 17 patients planned for each group, and treatments are administered in the emergency department. During the study, participants will have their pain levels measured one hour after enrollment as the primary outcome. Secondary outcomes include the duration of pain relief over 24 hours, changes in pain and discomfort scores one hour after treatment, and the length of stay in the emergency department. The study monitors participants closely during their emergency department visit, and total participation corresponds with their treatment and observation in this setting.