Students

Researchers are investigating the effects of the PAX Good Behavior Game GBG in Swedish primary schools to address growing concerns of mental health issues among children and stress-related symptoms in teachers. This cluster-randomized controlled trial involves 28 schools and about 84 teachers, aiming to improve student well-being and reduce teacher stress. The study compares PAX GBG to active control interventions that also provide teacher training but with different content. The trial includes extensive measurements over two years, including self-assessments, classroom observations, sound level monitoring, sick leave data, and qualitative interviews. Teachers randomized to the PAX GBG group receive a two-day training on ten specific tools designed to promote prosocial and focused behaviors in classrooms, including a team-based game rewarding good behavior. Control schools choose between two alternatives Count On Me, a math fluency application for pupils, or a Collegial Learning Community intervention focused on professional development for teachers. Both groups receive similar amounts of training and supervision, including multiple sessions during the school year. The interventions are integrated into regular classroom activities starting in grade 1 through grade 3. Participants include approximately 2200 pupils and their teachers, with data collected through various methods such as questionnaires, standardized tests, observer ratings, and registry data. Measurements occur at multiple time points over two years, focusing on pupil well-being, teacher stress, classroom behavior, noise levels, and implementation fidelity. The study also evaluates cost-effectiveness by comparing health outcomes and related expenses. Safety and adverse events are monitored through teacher reports and interviews, ensuring comprehensive assessment of the interventions impact.

This research aims to monitor participants who previously received TSC-100 or TSC-101 T-cell receptor engineered T-cell TCR-T therapies in the TSCAN-001 study. The goal is to assess the long-term safety and efficacy of these investigational treatments over a 15-year period following their administration, focusing on people treated for conditions such as AML, ALL, and MDS. Participants will not receive any new study drug during this long-term follow-up study. Instead, they will be observed after completing the initial TSCAN-001 trial, while continuing any other cancer treatments as necessary. Monitoring will include a period lasting 15 years from the date of their original TCR-T cell therapy. During the study, participants will be evaluated for treatment-emergent adverse events to assess safety and tolerability. Researchers will also monitor overall survival, relapse-free survival, and progression-free survival over the 15 years. This observational study involves regular assessments to track long-term outcomes without administering additional investigational treatments.

Researchers are conducting a master protocol trial designed to efficiently study several different drugs for children and young adults with various types of cancer. This approach allows multiple clinical trials under one common research plan, with each trial focusing on specific cancers like desmoplastic small round cell tumor, synovial sarcoma, and Ewings sarcoma. New drug studies may be added over time as new treatments emerge. Participation depends on how long the treatment benefits last. The study evaluates combinations of drugs given in cycles, including intravenous and oral medicines such as ramucirumab, cyclophosphamide, vinorelbine, gemcitabine, docetaxel, abemaciclib, irinotecan, and temozolomide. Different treatment groups receive specific drug combinations tailored to the cancer type, with treatment cycles lasting 21 or 28 days depending on the regimen. Each group is randomized to receive either an experimental drug combination or an active comparator without any blinding. Participants will be involved from screening through treatment and monitored regularly. Researchers will assess how many participants are assigned to each specific intervention plan within the first four weeks and track treatment effects. Participants must have measurable or evaluable disease, adequate organ function, and meet performance status criteria. Female participants of childbearing potential undergo pregnancy testing and must use contraception during and after treatment. Safety, adherence, and side effects are carefully monitored throughout the study, which is expected to continue until 2027.

Researchers are evaluating the use of CD19 CAR-T cell therapy in adult patients newly diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia Ph ALL. This open-label, multicenter study aims to assess how effective and safe this treatment is for this specific group of leukemia patients. Additional goals include studying how the CAR-T cells grow and persist in the body, as well as their effect on B-cell levels. Participants will receive an intravenous infusion of CD19 CAR-T cells at a dose of 2 x 106 CAR T cells per kilogram of body weight. The study includes approximately 50 adult patients and is designed as a single-arm trial without a comparison group. The treatment is administered once, followed by monitoring and evaluation periods. During the study, patients will be closely monitored for treatment response and safety. Key assessments include measuring the complete molecular response rate 28 days after infusion and tracking outcomes such as leukemia-free survival, overall survival, and relapse incidence over two years. Patients will undergo blood tests, genetic testing, heart function evaluations, and be observed for any infections or other health changes. Participation involves signing informed consent and agreeing to contraception measures if of childbearing potential.

Researchers are evaluating the safety and effectiveness of a liposomal mitoxantrone combination regimen in treating relapsed and refractory solid tumors in children, adolescents, and young adults aged 6 to 24 years. This prospective, single-arm, multicenter clinical study aims to improve the objective response rate compared to historical data and to assess related side effects. The study focuses on specific tumor types including bone and soft tissue tumors and neuroblastoma among others. Participants will receive a treatment regimen combining mitoxantrone liposome, capecitabine, and anlotinib over 4 to 6 cycles, each lasting 21 days. Capecitabine is given twice daily on days 1 to 14, while anlotinib dosage is adjusted based on body weight and administered for 14 days per cycle. Those showing partial response or better may receive additional local treatments such as surgery or radiotherapy. During the study, participants will have regular checkups and tests to monitor tumor status, blood parameters, and other relevant health indicators. The main measurement is the objective response rate after up to 6 treatment cycles. Other outcomes include disease control rate, progression-free survival, overall survival, and safety monitoring for up to one year after treatment. The total observation period includes follow-up assessments to evaluate lasting effects and adverse events.

Researchers are evaluating a mindfulness program specifically adapted for Hispanic young adults aged 18 to 25 who engage in heavy episodic drinking. This randomized control trial aims to test the feasibility and acceptability of an 8-week Mindfulness-Based Stress Reduction MBSR program designed to reduce problematic drinking among this population. The study seeks to understand how well this culturally and developmentally tailored intervention works in a real-world setting. Participants will be randomly assigned to one of two groups an intervention group receiving weekly 1.5-hour in-person mindfulness sessions over 8 weeks at Florida International Universitys MMC campus, or an assessment-only control group. Both groups will complete online surveys and provide fingerprick blood samples to measure alcohol biomarkers, as well as have their heart rate and blood pressure measured at four timepoints baseline, 1 month, 2 months, and 3 months after baseline. The intervention group will also receive Contingency Management incentives to encourage attendance. Throughout the study, participants will spend up to 16 hours over approximately 14 weeks completing assessments, participating in the mindfulness sessions if assigned, and attending follow-up evaluations. Researchers will measure outcomes such as program acceptability, attendance, retention, changes in heavy drinking behavior, alcohol consumption, and perceived stress. Safety and minimal risks like discomfort from assessments or blood sampling will be monitored during the study.

The GEROS Project is designed to develop and implement a Service-Learning program that combines Comprehensive Geriatric Assessment CGA and health promotion for older adults aged 60 and above. It involves university students from various health-related fields and aims to foster intergenerational learning and community engagement. The study follows a non-experimental mixed-method design and focuses on evaluating frailty, intrinsic capacity, quality of life, and other health indicators in participating older adults. Participants will receive a series of three sessions at the University of Vic - Central University of Catalonia, where students supervised by health professionals conduct CGA evaluations. Following the assessment, users receive a report with their CGA results along with personalized health education and recommendations. The program integrates practical student training with real-world health promotion for older adults. During the study, researchers will assess frailty and quality of life at baseline, and measure satisfaction and self-perceived knowledge and skills of both students and older adult participants after the intervention sessions. Data will be collected through questionnaires and recorded using REDCap. The study supports active aging and aligns with global health and equality goals, with total participation spanning up to 2-4 weeks after intervention.

This research aims to study how mind and body activities, including those done with virtual reality VR, affect brain health, thinking skills, and emotional well-being in college students aged 18 to 25 years. The study uses a detailed approach that looks at thinking, emotional health, biological markers, and brain imaging to understand how these activities might help. Researchers believe that three types of activitiesMindfulness-Based Stress Reduction MBSR, Qigong, and High-Intensity Functional Training HIFTwill improve thinking and well-being after three months compared to before starting. Participants will be divided randomly into groups to try either traditional or VR versions of these three activities, each lasting 12 weeks. Study 1 involves 174 students doing online HIFT, Qigong, or MBSR sessions, while Study 2 includes 45 students doing the same activities but using VR. Each intervention includes guided group sessions and individual practice. Before and after the 12-week programs, medical, mental, and physical tests are done, with brain scans and biological samples collected in Study 1. There is also a follow-up 12 weeks after the interventions to check on physical and emotional well-being through online questionnaires. During the study, participants will complete various tests measuring memory, attention, thinking skills, psychological symptoms, self-esteem, mindfulness, sleep quality, and diet. Physical fitness and health measures like heart rate, muscle strength, balance, and brain imaging will be done before and after the interventions. The study also tracks changes in gut microbiota and emotional status. For the VR group, usability and acceptance of the VR system are evaluated. The entire study includes careful monitoring and assessments over several months to understand the effects of these interventions on brain and psychological health.

This research aims to build evidence for a youth firearm violence prevention program in Washington D.C., a city facing disparities in youth firearm violence outcomes. It focuses on how participation in the summer youth employment program called The T.R.I.G.G.E.R Project, designed to address the root causes of gun violence, relates to youth behavioral outcomes such as pro-social involvement, aggression, and attitudes toward firearms. Participants will be involved in The T.R.I.G.G.E.R Project over several years, with waves of youth participating in summer youth employment programs from 2022 through 2025. The program includes components like summer employment, social and emotional learning, future orientation, adult and peer support, critical consciousness, and civic engagement, all aimed at addressing firearm violence causes. Youth participants will complete four surveys over one year to track changes in attitudes and behaviors a pre-test at the program start, then post-tests 2-4 weeks, 6 months, and 12 months after the program ends. Researchers will measure changes in civic efficacy, pro-social involvement, violence-related attitudes, aggressive behavior, firearm carriage frequency, firearm use, and firearm aggression throughout these time points.

Researchers are evaluating a new teaching model designed to improve clinical communication, empathy, and emotion regulation in pediatric nursing students. This study compares traditional pediatric nursing education with an innovative approach that combines AI communication simulation and human library storytelling. The goal is to create a more realistic and immersive learning experience to better prepare students for real clinical situations, addressing challenges like nervousness and difficulty applying classroom learning in practice. The study involves two groups one receiving standard pediatric nursing education including lectures, case discussions, and clinical internships, and the other receiving the same curriculum plus the innovative AI-based communication simulation and human library narrative activities. These interventions are delivered during the nursing semester according to course schedules and teaching environments. The research uses a randomized controlled design to compare the effectiveness of these teaching methods. Participants will complete various assessments at baseline, mid-semester 8-9 weeks, and end of semester 18 weeks, including communication skills scales, empathy questionnaires, and emotion regulation evaluations. Qualitative data are collected through structured reflections and focus group interviews to explore students learning experiences and emotional changes. The study runs from August 2026 to July 2027, with continuous monitoring of outcomes to understand the impact of the integrated teaching intervention.