Actively Recruiting
Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2026-02-12
800
Participants Needed
1
Research Sites
449 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying chronic liver diseases and tumors, including non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), cirrhosis, and hepatocellular carcinoma (HCC). These conditions can be caused by viral infections like hepatitis B, C, and D or lifestyle factors such as overeating and lack of exercise. The goal is to develop better understanding and new treatments by analyzing liver tissues and tumors at the single-cell level to identify therapeutic targets and improve patient outcomes. The study involves creating patient-derived preclinical models, such as spheroid cultures and mouse xenograft models, to test new treatment strategies. Blood samples and tissue biopsies are collected during surgeries, biopsies, or diagnostic tests. Researchers use advanced molecular techniques like single-cell RNA sequencing to examine tumor heterogeneity and the liver environment, aiming to discover new biomarkers and treatment predictors. Participants will undergo procedures as part of their care, including hepato-bilio-pancreatic surgery, biopsies, or locoregional treatments. Blood samples are taken during these procedures to support research. Researchers will monitor surgery outcomes over an average of eight years. By studying patient samples and clinical data, the team aims to improve personalized medicine approaches and identify new preventive and therapeutic targets for chronic liver diseases and liver cancer.
CONDITIONS
Brief Title
"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with chronic liver disease (viral or non-viral)
- Patients diagnosed with at least one liver nodule scheduled for biopsy
- Patients planned for hepatobiliary surgery as part of care
- Patients for whom locoregional treatment for hepatocellular carcinoma (HCC) is indicated
- Patients able to understand study information and provide written informed consent
- Patients affiliated with the French social security system
You will not qualify if you...
- Minor patients
- Patients under legal protection or unable to provide consent
- Patients in situations of social fragility
- Pregnant or breastfeeding women
- Patients who have not signed informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Variable, depending on care schedule
Participants undergo diagnostic procedures such as blood sampling as part of their routine care to help characterize their liver condition.
1 or more visits depending on diagnostic tests
Duration - Up to hospital discharge
Participants who undergo hepato-bilio-pancreatic surgery as part of their routine care have blood samples taken during surgery and receive immediate post-operative monitoring.
1 surgical visit plus approximately 6 post-operative visits
Duration - Single procedure visit
Participants scheduled for biopsy or locoregional treatment have additional biopsy samples and blood drawn to support research analyses.
1 visit (in-person)
Duration - Up to 8 years
Participants with chronic liver disease are followed over time to monitor disease progression and support ongoing research.
Periodic visits as part of routine care
Trial Site Locations
Total: 1 location
1
PU-PH, Directeur de l'UMR_S1110 Unité Inserm d'affiliation : UMR_S1110
Strasbourg, France, 67000
Actively Recruiting
Research Team
T
Thomas BAUMERT, DR
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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