Studying Heart Effects of Chemoradiotherapy in Adults with Advanced Non-Small Cell Lung Cancer Using ECG and Cardiac MRI Over Two Years

What this Trial Is About

Researchers are investigating the effects of radiotherapy on the heart in patients with loco-regional advanced non-small cell lung cancer NSCLC who are planned for curative treatment with chemoradiotherapy. The study aims to understand both early and late heart toxicity caused by this treatment and to assess the baseline heart health of these patients. It focuses on heart function and potential heart disease using ECG and cardiac magnetic resonance imaging MRI. Patients will be followed in two study groups one group will have cardiac MRI and ECG tests before starting treatment and again at 6, 12, and 24 months after radiotherapy. The second group will have one cardiac MRI and ECG test between 12 and 24 months after treatment if not included in the first group. All patients receive radiotherapy alone or combined with chemotherapy with curative intent. Participants will undergo heart function assessments using ECG and cardiac MRI at specified intervals to detect structural changes and subclinical heart disease after radiotherapy. Researchers will monitor overall survival, heart function changes, treatment-related adverse events, and cardiovascular mortality over two years. The study involves regular imaging and clinical evaluations to understand the hearts response to treatment and ensure patient safety during follow-up.

COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA)