Actively Recruiting
Clinical Relevance of Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
Led by Chonnam National University Hospital · Updated on 2026-05-12
150
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
C
Chonnam National University Hospital
Lead Sponsor
K
Korean Cardiac Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating myocardial infarction with non-obstructive coronary arteries (MINOCA), a condition affecting about 5-10% of acute myocardial infarction patients. The study focuses on coronary microvascular dysfunction (CMD), which is considered a major cause of MINOCA, and evaluates clinical outcomes based on CMD presence. This observational study aims to clarify the different causes of MINOCA and their impact on patient prognosis, addressing the challenges in diagnosis and management. The study uses diagnostic tests including intravascular imaging with optical coherence tomography (OCT), invasive physiologic assessments like fractional flow reserve (FFR), coronary flow reserve (CFR), and index of microcirculatory resistance (IMR), as well as non-invasive assessments using N-13 ammonia positron emission tomography (PET). Participants are grouped into those with CMD and those without CMD, and assessments are performed to evaluate coronary microvascular function following the latest diagnostic guidelines. Participants will be monitored over a two-year period to assess major adverse cardiac and cerebrovascular events (MACCE), including cardiac death, all-cause death, myocardial infarction, repeat revascularization, stroke, and heart failure readmission. Additional measurements include changes in left ventricular ejection fraction and coronary flow reserve. Data collection includes invasive and non-invasive imaging and physiologic tests, with regular follow-up to evaluate long-term clinical outcomes.
CONDITIONS
Brief Title
Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 19 years or older with acute myocardial infarction
- Rise and/or fall of cardiac troponin above the 99th percentile with ischemic signs or symptoms
- Non-obstructive coronary arteries defined as less than 50% diameter stenosis or fractional flow reserve (FFR) greater than 0.80
- No previous history of coronary artery disease
- Underwent invasive coronary angiography within 24 hours after presentation
- Eligible for invasive and non-invasive coronary physiologic assessment
You will not qualify if you...
- Presence of obstructive coronary arteries
- Alternate diagnoses such as sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection, or other cardiomyopathies
- Cardiogenic shock or cardiac arrest
- Non-cardiac conditions with life expectancy less than 1 year
- Pregnancy or lactation
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within a few days after screening
Participants undergo diagnostic tests including intravascular imaging, invasive physiologic assessments, or non-invasive physiologic assessments to evaluate coronary microvascular dysfunction.
1 to 2 visits depending on diagnostic procedures
Duration - 2 years
Participants are monitored to assess clinical outcomes including major adverse cardiac events and changes in cardiac function over 2 years.
Periodic follow-up visits over 2 years
Trial Site Locations
Total: 1 location
1
Chonnam National University Hospital
Gwangju, Gwangju, South Korea, 61469
Actively Recruiting
Research Team
Y
Young Joon Hong, MD, PhD
S
Seung Hun Lee, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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