Study of Blood Flow Changes in the Superior Mesenteric Artery and Their Link to Acute Gastrointestinal Injury in Critically Ill Adults

What this Trial Is About

Researchers are examining how blood flow in the superior mesenteric artery SMA changes after feeding in critically ill patients in the intensive care unit ICU. The study seeks to understand the connection between these blood flow changes and the risk of Acute Gastrointestinal Injury AGI, aiming to develop a model that predicts AGI risk based on SMA blood flow reactivity. This research focuses on improving enteral nutrition safety and patient outcomes by tailoring feeding strategies using intestinal blood flow information. The study uses enteral nutrition with intact protein formulas delivered through a nasogastric tube, starting at a rate of 20 ml per hour for 24 hours. Feeding adjustments are made based on real-time monitoring of SMA blood flow using bedside Doppler ultrasound. This observational approach allows researchers to closely observe how intestinal blood flow responds to feeding and its relation to gastrointestinal function. Participants will be monitored from enrollment through at least three days of treatment, with assessments focusing on feeding intolerance and gastrointestinal status. Researchers will use ultrasound to track SMA blood flow changes and evaluate hemodynamic indicators. The study aims to identify patterns in blood flow that predict gastrointestinal injury, enhancing personalized nutrition plans. Overall participation will include these monitoring and feeding evaluations during the hospital stay.

Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients