Study of Brain Activity Using Transcranial Magnetic Stimulation in Adults with Cyclic Vomiting Syndrome Compared to Healthy Adults

What this Trial Is About

Researchers are studying differences in brain activity between people with cyclic vomiting syndrome CVS and healthy individuals. This exploratory study uses a non-invasive brain stimulation technique called Transcranial Magnetic Stimulation TMS to assess how the brains cortex responds in these two groups. The goal is to understand cortical excitability patterns in CVS compared to healthy controls. The study involves stimulating the motor cortex with paired-pulse TMS, which measures the brains response through muscle activity. Different timing intervals between pulses are used to evaluate various types of brain inhibition and facilitation. The study includes two groups participants diagnosed with CVS and healthy control subjects without CVS. Autonomic function is also monitored using continuous EKG recordings to see how it might affect brain excitability. Participants will attend multiple study sessions over up to 12 months where brain and heart activity will be assessed. Measurements include paired-pulse ratios, motor thresholds, cortical silent periods, and heart rate variability. Clinical, demographic, and autonomic data will be collected to analyze their relationship with brain excitability. The study aims to gather detailed information about brain function in CVS while monitoring participant health throughout the study period.

Cortical Excitability in Cyclic Vomiting Syndrome