Actively Recruiting
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Disease
Led by Istituto Auxologico Italiano · Updated on 2025-05-07
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the different clinical presentations of motor neuron disease (MND) in patients seen at the Neurology Department of the Istituto Auxologico Italiano. The study aims to identify specific clinical types of MND and understand how these types can improve knowledge of the disease mechanisms and help predict outcomes more accurately. This is an observational study without drug or treatment interventions. Participants will undergo clinical evaluations using validated scales, neurophysiological and neuroradiological assessments, and neuropsychological testing. Biological samples may also be collected for genetic testing and biomarker analysis if needed. The study focuses on observing and characterizing the disease rather than testing treatments. During the study, participants will be regularly assessed to identify various MND phenotypes at diagnosis and after one year. Researchers will track the number of patients with classic ALS, bulbar ALS, lower motor neuron (LMN) phenotypes like flail arm or leg, and upper motor neuron (UMN) phenotypes such as pyramidal ALS or primary lateral sclerosis. This monitoring will help improve understanding of disease variability and progression. The study is set to continue until the end of 2026.
CONDITIONS
Brief Title
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of amyotrophic lateral sclerosis or other motor neuron disease
- Age 18 years or older
- Willingness to participate in the study
You will not qualify if you...
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants are observed to study phenotypic variability in motor neuron diseases over time.
Visits at baseline (diagnosis) and at 1 year
Trial Site Locations
Total: 1 location
1
Ospedale San Luca
Milan, MI, Italy, 20149
Actively Recruiting
Research Team
N
Nicola Ticozzi, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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