Actively Recruiting
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis
Led by Sensorion · Updated on 2026-05-08
100
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to better understand adults who develop bilateral sensorineural hearing loss, a type of hearing impairment affecting both ears that begins in adulthood and is likely caused by genetic factors. The study focuses on patients who carry mutations in the GJB2 gene, which is linked to hearing loss, to assess how their condition changes over time. Participants will undergo genetic testing to identify mutations in the GJB2 gene and receive audiological assessments to evaluate their hearing ability. Those found to carry the GJB2 mutation will be followed for two years to monitor the progression of their hearing impairment and related mood changes. During the study, participants will be evaluated through genetic and hearing tests, as well as mood assessments. The main outcome measured is the evolution of hearing loss over two years in adults with early-onset hearing impairment linked to GJB2 mutations. The study also collects data on genetic and audiological features at a unique visit. This involvement allows researchers to observe how hearing loss develops and affects patients over time.
CONDITIONS
Brief Title
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female or Male patients aged 30 to 55 years
- Bilateral hearing loss first noticed after the age of 16 years
- Documented genetic test results showing mutations in the GJB2 gene
You will not qualify if you...
- Deafness with a known, non-genetic cause
- Unable or unwilling to comply with all study procedures according to the investigator's opinion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo genetic testing and audiological assessments to characterize hearing loss and identify mutations in the GJB2 gene.
1 visit (in-person)
Duration - 2 years
Participants carrying mutations in the GJB2 gene are followed to monitor the evolution of hearing impairment and mood over 2 years.
Periodic visits over 2 years
Trial Site Locations
Total: 2 locations
1
The University of South Florida Board of Trustees
Tampa, Florida, United States, 33620
Actively Recruiting
2
CHU Gui de Chauliac
Montpellier, France, 34295
Actively Recruiting
Research Team
L
Lionel HOVSEPIAN, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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