Study to Understand Hearing Loss Starting in Adulthood with GJB2 Gene Mutations in Adults Aged 30 to 55

What this Trial Is About

This research aims to better understand adults who develop bilateral sensorineural hearing loss, a type of hearing impairment affecting both ears that begins in adulthood and is likely caused by genetic factors. The study focuses on patients who carry mutations in the GJB2 gene, which is linked to hearing loss, to assess how their condition changes over time. Participants will undergo genetic testing to identify mutations in the GJB2 gene and receive audiological assessments to evaluate their hearing ability. Those found to carry the GJB2 mutation will be followed for two years to monitor the progression of their hearing impairment and related mood changes. During the study, participants will be evaluated through genetic and hearing tests, as well as mood assessments. The main outcome measured is the evolution of hearing loss over two years in adults with early-onset hearing impairment linked to GJB2 mutations. The study also collects data on genetic and audiological features at a unique visit. This involvement allows researchers to observe how hearing loss develops and affects patients over time.

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