Actively Recruiting
Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes
Led by Sensorion · Updated on 2026-04-06
180
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to follow the natural history of non-syndromic hearing loss caused by mutations in two genes (GJB2 or OTOF) in children up to 16 years of age.
CONDITIONS
Official Title
Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 16 years or younger at the time of consent for cohort 1 or 10 years or younger for cohort 2
- Diagnosed with non-syndromic, bilateral, mild to profound sensorineural hearing loss
- Documented genetic test showing mutation(s) in GJB2 or OTOF genes
- Signed informed consent according to local rules
- May have no cochlear implant or have unilateral or bilateral cochlear implants
You will not qualify if you...
- Other types of deafness such as unilateral deafness, persistent conductive deafness, malformation syndromes, syndromic deafness, or familial deafness linked to genes other than GJB2 or OTOF
- Genetic testing shows mutations in genes other than GJB2 or OTOF
- Unable or unwilling to follow all study procedures and protocol requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Necker Hospital
Paris, France
Actively Recruiting
Research Team
L
Lionel HOVSEPIAN, MD
CONTACT
G
Géraldine HONNET, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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