Study of Fat Tissue Changes in Adults with Obstructive Sleep Apnea Compared to Healthy Adults

What this Trial Is About

Researchers are investigating how obstructive sleep apnea OSA affects fat tissue and its role in increasing the risk of cardiovascular disease. This study focuses on examining the cellular and molecular changes in fat tissue of adults with OSA compared to healthy individuals. It aims to better understand how damaged fat tissue may contribute to insulin resistance, inflammation, and higher blood pressure in people with OSA. The study involves comparing fat tissue samples from two groups those with obstructive sleep apnea defined by an Apnea Hypopnea Index of 5 or higher and those without it AHI less than 5. Researchers will analyze markers of cellular damage in the fat tissue, such as p16 and gamma H2AX, to identify differences. The study is observational and does not involve treatment, focusing on tissue analysis and cardiovascular health markers. Participants will undergo assessments including fat tissue sampling to measure cellular damage markers, body composition analysis, blood pressure monitoring over 24 hours, evaluation of vascular function, and insulin sensitivity tests. The primary outcome is the prevalence of specific damaged cells in fat tissue. The total study duration and visits are arranged to gather this data, with no investigational treatments administered. The study is sponsored by the Mayo Clinic and includes adults aged 18 to 60 years.

A Cross-sectional Study Examining Adipose Tissue in Obstructive Sleep Apnea