CT-Angiography-Derived Plaque Characteristics on Cardiac Events in Patients Deferred by Invasive Fractional Flow Reserve

What this Trial Is About

Researchers are studying patients with chronic coronary syndromes (CCS) to understand how coronary computed tomography angiography (CTA) can identify plaque characteristics linked to future cardiac events in patients whose treatment was deferred based on invasive fractional flow reserve (FFR). Although FFR-guided percutaneous coronary intervention (PCI) has improved outcomes compared with angiography-guided PCI, cardiac events still occur long-term in patients whose PCI was deferred. The study focuses on the relationship between high-risk plaques seen on CTA and future cardiac events in these patients. This observational study includes patients who had a coronary CTA within 90 days before undergoing invasive coronary angiography (ICA) with FFR pressure measurement. The study examines clinical features and plaque characteristics on CTA in deferral lesions identified by FFR. Patients receive standard diagnostic testing including CTA and ICA with FFR, without additional treatments assigned by the study. Participants will be followed to track cardiac events at both the patient and lesion levels from 2018 to 2026. Researchers will review clinical data, imaging findings, and outcomes to identify plaque features associated with future cardiac events. The study does not involve treatment interventions but focuses on diagnostic imaging and long-term observation to better understand risk in this patient group.

CT-Angiography Plaque Characteristics and Events in Deferral Patients by Invasive Fractional Flow Reserve