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Led by M.D. Anderson Cancer Center · Updated on 2026-02-27
60
Participants Needed
3
Research Sites
N/A
Total Duration
Researchers are developing and testing a culturally tailored yoga therapy program for cancer patients undergoing hematopoietic stem cell transplantation HSCT in India, Tanzania, and the United States. This program aims to address cultural norms and provide psychosocial support through yoga to improve patient well-being during and after transplant. The study focuses on creating a sensitive, patient-centered approach by involving patients from each center in interviews and program design. Participants will engage in gentle yoga movements, breathing exercises, relaxation techniques, and meditation tailored to their individual needs. The program includes up to 12 yoga sessions, delivered three times per week starting two weeks before the transplant and continuing throughout the first 30 days of hospitalization. Sessions may be conducted in person, via telehealth, or a combination of both. Participants will also complete questionnaires about symptoms, anxiety, depression, quality of life, and treatment expectations, along with exit interviews. During the study, researchers will monitor adherence to the yoga sessions and completion of follow-up assessments at two months post-transplant. Participants will be assessed using the Patient Health Questionnaire-8 PHQ-8 over about one year. The study includes interviews and questionnaires to evaluate the programs acceptability and impact. The total involvement includes the yoga program during hospitalization and follow-up assessments to understand patient outcomes and feasibility of the intervention.
CONDITIONS
Cultural Tailoring and Pilot Testing of an Inpatient Yoga Therapy Program for Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation in India, Tanzania, and the United States
L
Lorenzo Cohen, PHD
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M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Yoga Therapy Program (Study Group) | Current Supportive Care (No Adjunctive Yoga) |
|---|---|---|
| What it is | A structured yoga therapy program culturally adapted for inpatients undergoing HSCT, offered as up to 12 sessions starting two weeks before and continuing through the first month after transplant. | Supportive care typically includes medical management, symptom control, and psychosocial support during HSCT hospitalization, but does not systematically incorporate yoga therapy. |
| Role in trial | All enrolled participants receive yoga therapy in addition to usual supportive care; the study evaluates program feasibility and outcomes. | Patients receive standard supportive care based on institutional protocols, without additional yoga therapy as part of routine care. |
| Primary use | Intended to provide additional psychosocial and symptom management support during HSCT by using yoga therapy tailored to local culture and patient needs. | Aims to minimize treatment-related side effects, support emotional wellbeing, and manage symptoms during and after HSCT without structured yoga interventions. |
| How it is given or performed | Yoga sessions occur in-person, up to three times per week, beginning two weeks before transplant and during the first 30 days post-transplant. Sessions are adapted according to local language and culture. | Physicians, nursing staff, and psychosocial teams provide monitoring, medication, and emotional support. Complementary therapies like yoga are not standard or routinely organized. |
| Evidence status | Yoga therapy is being evaluated for feasibility, acceptability, and its effects on patient-reported outcomes such as mood, symptom burden, and quality of life. Published evidence for routine clinical benefit in HSCT patients remains limited and is under active investigation. | Current supportive care is supported by consensus evidence and ongoing research for its role in managing symptoms, mental health, and quality of life during HSCT, but does not include yoga therapy as a routine component. |
| Important limitations | The intervention is not compared to a randomized control group in this trial. Results will be limited by the single-group design and may not be generalizable to all settings or patient populations. | Standard supportive care approaches can vary across institutions and countries. Symptom burden, distress, and quality of life may remain significant concerns for patients during HSCT without adjunctive therapies. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote) for consent and eligibility assessment
Duration - Up to 6 weeks starting two weeks before transplant and continuing throughout the first 30 days post-transplant
Participants take part in a culturally tailored yoga therapy program including gentle movements, breathing exercises, relaxation techniques, and meditation, customized to their needs.
Up to 12 yoga sessions, approximately 3 sessions per week, delivered in person, via telehealth, or a combination
Duration - Up to 2 months after transplant
Participants complete questionnaires and an exit interview to assess symptoms, mental health, quality of life, and treatment expectations.
4 questionnaire completions and 1 exit interview conducted by phone or video call
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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Smitha Mallaiah, Vijaya Majumdar, Scherezade K Mama...
https://pubmed.ncbi.nlm.nih.gov/41791008/M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborating Sponsor
