Actively Recruiting
Decoding Motor Imagery From Non-invasive Brain Recordings as a Prerequisite for Innovative Motor Rehabilitation Therapies
Led by Hospices Civils de Lyon · Updated on 2026-03-19
35
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how brain signals related to movement and motor imagery can be decoded from non-invasive recordings to guide innovative motor rehabilitation therapies. The study focuses on understanding patterns called event-related desynchronization (ERD) and synchronization (ERS) in specific brain frequency bands, particularly mu and beta. These patterns are linked to movement preparation and execution but may be better understood by examining transient beta bursts rather than averaged signals. The study includes healthy adults and stroke patients with upper-limb motor deficits to assess how brain activity changes after stroke and during motor tasks. Participants will be divided into two groups: healthy controls and stroke patients with motor impairments. The healthy group will undergo Magnetic Resonance Imaging (MRI) to create individualized 3D-printed head casts for use during high-precision Magnetoencephalography (hpMEG) sessions that stabilize head movement and improve brain signal localization. Both groups will participate in EEG recordings during motor imagery and movement tasks. The study will compare the hpMEG-based approach to standard EEG-based brain-computer interface (BCI) techniques and develop subject-specific models to decode movement features such as onset, offset, type, and amplitude. During the study, participants will complete motor imagery and wrist movement tasks while brain activity is recorded using hpMEG and EEG techniques. Researchers will analyze beta and mu frequency bursts and develop personalized models to improve decoding accuracy. Assessments include MRI scans, MEG and EEG recordings, and detailed analysis of brain signal patterns related to motor control. The study aims to optimize EEG-based BCI training and evaluate this method's feasibility with stroke patients. Participant involvement lasts up to two years, during which brain activity and motor performance will be closely monitored and modeled.
CONDITIONS
Brief Title
Decoding Motor Imagery From Non-invasive Brain Recordings as a Prerequisite for Innovative Motor Rehabilitation Therapies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy subjects aged over 18, male or female, for the control group
- Right-handed individuals only
- Registered with the French healthcare system
- Motivated to participate in the study
- Normal or corrected vision
- Adequate knowledge of French to follow directions
- Ability to listen, understand instructions, and provide written informed consent
- No history of neurological or psychiatric disease
- No physical disability of the arms or wrists
- No use of drugs affecting the central nervous system or drug abuse
- Stroke patients over 18 years, male or female, not in acute stroke phase, for patient group
- Stroke patients with motor disorders in at least one upper limb and no cognitive deficits
- Entitled to a social security scheme
- Motivated to participate with normal or corrected vision
- Sufficient French language understanding
- Ability to listen, understand instructions, and provide written informed consent
You will not qualify if you...
- Claustrophobia incompatible with MEG and MRI
- Motor impairment in control group or severe traumatic brain injury
- Chronic stroke in both groups
- History of skin disease or severe skin allergies
- MRI within 2 weeks prior to experiment
- Implanted metal-containing dental apparatus, pacemakers, cochlear implants, or other metallic objects
- Occupational exposure to metals
- Pregnant or lactating women
- Unable to tolerate sitting for longer than 2 hours
- Alcohol dependence or drug consumption within 24 hours prior to experiments
- Medications strongly affecting MEG or EEG (e.g., antidepressants, stimulants)
- Inability or unwillingness to comply with protocol
- Persons under guardianship or legal protection
- Emergency situations preventing consent
- Volunteers with contraindications to MEG, including pacemakers, implanted pumps, neurostimulators, cochlear implants, metal prostheses, aneurysm clips, or ferromagnetic foreign bodies
- Neurosurgical ventriculoperitoneal shunt valves
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session per modality
Participants undergo MRI scans to create 3D head models and headcasts, followed by MEG and EEG recordings to measure brain activity related to motor imagery and execution.
1 MRI session, 1 MEG session with 3D-printed headcast, and 1 EEG session using electrode localization
Duration - Up to 2 years
Participants' brain activity data from EEG and MEG recordings are analyzed to develop subject-specific neurophysiological models for decoding motor imagery and execution.
Periodic data analysis without additional visits
Trial Site Locations
Total: 1 location
1
Centre de Recherche en Neurosciences de Lyon - INSERM U1028
Bron, France, 69675
Actively Recruiting
Research Team
J
Jérémie MATTOUT, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here