Actively Recruiting
Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
Led by University of California, Los Angeles · Updated on 2025-10-14
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of California, Los Angeles
Lead Sponsor
U
University of Iowa
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how memory processes and consolidation happen during sleep by studying direct recordings from the human brain. This includes measuring activity from single neurons, groups of neurons, and brain signals during tasks involving real-life stories. The study aims to understand how these brain features relate to different parts of episodic memory and to explore how auditory and electrical stimulations during sleep might influence memory consolidation. Participants will receive auditory and electrical stimulations applied during sleep as part of the study. These interventions are studied to assess their effect on memory processes during sleep. The study involves patients undergoing depth electrode placement as part of their epilepsy treatment, allowing detailed brain recordings while performing behavioral tasks before and after sleep. Participants will stay in the hospital for 1 to 2 weeks, during which memory tests will be performed before and after sleep periods. Researchers will assess recognition accuracy and discriminability as primary outcomes, while secondary outcomes include measuring brain oscillations and neuronal replay during sleep. The study includes careful monitoring and assessments within this hospital stay to track memory changes and stimulation effects.
CONDITIONS
Brief Title
Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 with epilepsy undergoing depth electrode placement for clinical reasons
- Approval by epilepsy surgery team based on neuropsychological and psychiatric evaluations
- Willingness to provide informed consent and participate in the study
You will not qualify if you...
- Presence of neurological or psychiatric conditions other than epilepsy that increase patient risk
- Age below 18 or above 65 years
- Unwillingness to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 to 2 days contained within the participants' 1 to 2 week hospital stay
Participants receive auditory and electrical stimulation during sleep while memory tasks are performed before and after sleep.
1 to 2 visits during hospital stay
Trial Site Locations
Total: 1 location
1
University of California Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
A
Andreina Hampton
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
0
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