Studying Memory and Its Modulation During Awake and Sleep Cycles Using Brain Recordings and Stimulation in Adults with Epilepsy

What this Trial Is About

Researchers are investigating how memory processes and consolidation happen during sleep by studying direct recordings from the human brain. This includes measuring activity from single neurons, groups of neurons, and brain signals during tasks involving real-life stories. The study aims to understand how these brain features relate to different parts of episodic memory and to explore how auditory and electrical stimulations during sleep might influence memory consolidation. Participants will receive auditory and electrical stimulations applied during sleep as part of the study. These interventions are studied to assess their effect on memory processes during sleep. The study involves patients undergoing depth electrode placement as part of their epilepsy treatment, allowing detailed brain recordings while performing behavioral tasks before and after sleep. Participants will stay in the hospital for 1 to 2 weeks, during which memory tests will be performed before and after sleep periods. Researchers will assess recognition accuracy and discriminability as primary outcomes, while secondary outcomes include measuring brain oscillations and neuronal replay during sleep. The study includes careful monitoring and assessments within this hospital stay to track memory changes and stimulation effects.

Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles