Actively Recruiting
Neural Correlates of Real World Spatial Navigation in Humans
Led by Duke University · Updated on 2026-05-15
70
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how the brain supports real world spatial navigation by studying deep brain activity during memory and navigation tasks. The study focuses on understanding cognitive memory and behavioral factors like body, head, and eye movements that influence deep brain signals. It also evaluates the effects of deep brain stimulation aimed at enhancing memory. Participants with RNS implants will engage in tasks involving walking in a room, using treadmills, or navigating in virtual and augmented reality environments. The study uses devices like Meta Ray-Ban glasses to capture memories while recording brain activity. Deep brain stimulation is applied and various physiological signals such as heart rate, breathing, and skin conductance are monitored during these activities. Throughout the study, participants will complete questionnaires to assess emotional experiences and will be monitored using motion capture and eye-tracking. Key outcomes measured include spatial memory, changes in memory performance, and changes in brain oscillatory activity, collected over an average of 2 to 4 days per year until study completion. The study includes participants aged 12 to 70 years and involves both behavioral and device-based assessments.
CONDITIONS
Brief Title
Neural Correlates of Real World Spatial Navigation in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 12 years of age or older and has undergone RNS system placement
- Willing to provide informed consent and participate in the study
- Ability to read and write English fluently
You will not qualify if you...
- Unwilling to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Throughout study completion, an average of 2-4 days per year
Participants with RNS implants undergo deep brain stimulation device implementation and participate in memory and spatial navigation tasks including walking, treadmill, or controlled VR/AR environments while physiological signals and neural activity are recorded.
2 to 4 visits per year
Trial Site Locations
Total: 2 locations
1
University of California, Los Angeles
Los Angeles, California, United States, 90024
Actively Recruiting
2
Duke University
Durham, North Carolina, United States, 27705
Actively Recruiting
Research Team
G
Gabriela Vilchez
N
Nanthia Suthana, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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