Study of Brain Activity and Memory Using Deep Brain Stimulation During Real World and Virtual Spatial Navigation in People With RNS Implants Aged 12 to 70

What this Trial Is About

Researchers are investigating how the brain supports real world spatial navigation by studying deep brain activity during memory and navigation tasks. The study focuses on understanding cognitive memory and behavioral factors like body, head, and eye movements that influence deep brain signals. It also evaluates the effects of deep brain stimulation aimed at enhancing memory. Participants with RNS implants will engage in tasks involving walking in a room, using treadmills, or navigating in virtual and augmented reality environments. The study uses devices like Meta Ray-Ban glasses to capture memories while recording brain activity. Deep brain stimulation is applied and various physiological signals such as heart rate, breathing, and skin conductance are monitored during these activities. Throughout the study, participants will complete questionnaires to assess emotional experiences and will be monitored using motion capture and eye-tracking. Key outcomes measured include spatial memory, changes in memory performance, and changes in brain oscillatory activity, collected over an average of 2 to 4 days per year until study completion. The study includes participants aged 12 to 70 years and involves both behavioral and device-based assessments.

Neural Correlates of Real World Spatial Navigation in Humans