Studying Mania Caused by Deep Brain Stimulation in Parkinsons Disease Finding Factors That Predict This Side Effect to Improve Treatment

What this Trial Is About

Parkinsons Disease PD is a common neurodegenerative disorder that causes severe motor and non-motor symptoms. While medication can help manage symptoms, some patients do not respond well or experience side effects. Deep brain stimulation DBS is used for these cases to improve symptoms and quality of life, but it can sometimes cause serious neuropsychiatric side effects such as DBS-induced mania, which affects mood and can reduce treatment benefits. The exact causes of this condition are not well understood. This observational study compares two groups of PD patients who have had DBS surgery those who developed mania or a mixed mood episode after DBS and those who did not. The researchers will examine clinical records and neuroimaging data collected during routine care to identify if specific stimulation settings, electrode locations, or patient characteristics are linked to DBS-induced mania. They will use advanced brain imaging analyses to map the brain areas and networks affected by DBS that might be involved in this side effect. Participants medical history, stimulation parameters, and brain scans will be reviewed retrospectively. The main outcome is the location of brain tissue activation associated with mania after DBS. Researchers will also study clinical and sociodemographic factors and brain connectivity patterns to understand predictors of this condition. Data will be analyzed up to 24 months after the first manic symptoms. The study aims to improve knowledge about DBS-induced mania to help optimize treatments for PD patients receiving DBS.

Deep Brain Stimulation-Induced Mania in Parkinson's Disease