Actively Recruiting

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NCT06829147

A Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma(NPC)

Led by Sun Yat-sen University · Updated on 2025-02-17

500

Participants Needed

1

Research Sites

93 weeks

Total Duration

On this page

Sponsors

S

Sun Yat-sen University

Lead Sponsor

F

First People's Hospital of Foshan

Collaborating Sponsor

AI-Summary

What this Trial Is About

(I) AI Model for Diagnosing Lymph Node Metastasis We developed an AI model to help diagnose whether a single lymph node in nasopharyngeal cancer has spread. The model uses MRI images of the lymph node and the area around it. It includes: 1.Automatically identifying the lymph nodes and the primary tumor. 2.Analyzing MRI images of the lymph node and surrounding area. 3.Using MRI scans before and after chemotherapy to track changes in the lymph node. (II) AI Model for Predicting Lymph Node Metastasis We created an AI model that predicts whether a lymph node in a specific area has cancer. This model uses a combination of the primary tumor's pathology and MRI images of both the tumor and lymph node. It also tracks changes in the lymph node over time. The model includes: 1.Analyzing the tumor's pathology to identify specific lymphatic structures. 2.Using MRI scans to predict the likelihood of metastasis in a single lymph node. 3.Examining MRI scans before and after chemotherapy to help determine if the lymph node has metastasized. (III) Verifying and Analyzing the Benefits of the AI Model We are testing the AI model to see how well it works and its potential benefits, including: 1.Checking if the AI can correct past diagnoses of recurrent lymph nodes in nasopharyngeal cancer, which could help guide treatment plans for radiotherapy. 2.Testing the model using biopsy results from head and neck cancer patients to see if it can accurately detect negative lymph nodes. 3.Running clinical trials to test the AI model's safety and effectiveness in guiding radiation treatment for upper neck and single lymph node areas in nasopharyngeal cancer. 4.Analyzing the economic benefits of using the AI model in radiation treatment for nasopharyngeal cancer.

CONDITIONS

Official Title

A Deep Learning Model for Diagnosing Lymph Node Metastasis in Nasopharyngeal Carcinoma(NPC)

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Primary lesion pathologically confirmed as nasopharyngeal carcinoma (WHO types I, II, or III)
  • MRI scan performed at initial diagnosis before treatment, including transverse and coronal T1-weighted, T2-weighted, and T1-enhanced sequences
  • PET/CT scan performed at initial diagnosis before treatment
  • Agreement to cervical lymph node puncture and pathological exam if MRI and PET/CT results differ on lymph node status
Not Eligible

You will not qualify if you...

  • Prior cervical lymph node radiotherapy for any reason
  • Presence of other malignant tumors

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Department of Radiation Oncology, Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China, 510060

Actively Recruiting

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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