Actively Recruiting
Development of New Personalised 3D Preclinical Models of Pancreatic Neuroendocrine Tumours
Led by IRCCS San Raffaele · Updated on 2025-05-01
70
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a prospective observational study to create new personalized 3D preclinical models of pancreatic neuroendocrine tumors (PanNETs). These tumors have varied biological behavior and a dense vascular network, which plays a key role in disease progression and treatment response. The study aims to better understand tumor biology and drug responses by developing accurate models that replicate the tumor and its microenvironment. The study uses surgical specimens from patients undergoing pancreatic surgery for non-functioning PanNETs. If there is extra pathological tissue not needed for routine diagnosis, it will be used to create personalized 3D in vitro tumor models using advanced techniques like 3D bioprinting. These models will be maintained under dynamic conditions to better mimic the natural tumor environment. Participants will provide surgical tissue samples that are evaluated by pathology. The team will develop and study the personalized 3D models over time to explore tumor development and test drugs. The primary outcome is the successful development of these models from the day of surgery up to three years after surgery. The study involves no interventions beyond standard surgical care and tissue collection, with follow-up focused on laboratory research outcomes.
CONDITIONS
Brief Title
Development of New Personalised 3D Preclinical Models of Pancreatic Neuroendocrine Tumours
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who undergo pancreatic surgical resection for non-functioning pancreatic neuroendocrine tumor
- Age 18 years or older
- Provided informed consent to participate
You will not qualify if you...
- Diagnosis of neuroendocrine tumor outside the pancreas
- Age under 18 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Day of surgery
Participants undergo pancreatic surgical resection for non-functioning pancreatic neuroendocrine tumor.
1 visit (in-person)
Duration - From the day of surgery until 3 years from surgery
Participants' surgical specimens are used to develop personalised 3D preclinical models of PanNETs which are studied over time to understand disease mechanisms and for drug testing.
Trial Site Locations
Total: 1 location
1
IRCCS San Raffele Institute
Milan, MI, Italy, 20132
Actively Recruiting
Research Team
M
Massimo Falconi, Professor
A
Anna Battistella, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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