Studying Gut Microbes to Predict Return of High-Risk Colorectal Polyps After Removal in Adults Aged 40 to 75

What this Trial Is About

Researchers are investigating the characteristics of intestinal microbiota in patients who have a high risk of colorectal polyp recurrence after polypectomy. The study aims to understand how the microbial communities in the intestinal mucosal tissue relate to disease development and to develop a prediction tool based on microbiota and metabolites. This research is important for uncovering the causes of adenoma recurrence and improving future patient care. Participants undergoing colonoscopy with high-risk colorectal polyps will have 1-2 samples of large intestinal mucosa collected from the polyp and surrounding normal tissue. Stool samples and baseline information such as age, gender, and eating habits will also be gathered. Each patient will be followed for 3 years, with surveillance colonoscopies performed to check for polyp recurrence. Additional biopsies and stool samples will be collected at follow-up colonoscopies if possible, with all samples stored for microbiota sequencing and metabolomic analysis. During the study, researchers will assess the characteristics of intestinal microbiota at 24 months and develop a microbiota- and metabolite-based model to predict polyp recurrence over 36 months. Participants will provide samples and information throughout the follow-up period, allowing for detailed analysis of microbial changes and their relationship to recurrence. This observational study does not involve treatment but focuses on monitoring and collecting data over time to improve understanding of colorectal polyp recurrence.

Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy