Diet Education to Modify Bile Acid and Gut Microbiome for Preventing Colorectal Cancer in Adults with History of Colorectal Adenoma

What this Trial Is About

This research study focuses on individuals with a history of colorectal adenoma to evaluate how changing diet to include more plant-based and less animal-based foods affects factors linked to colorectal cancer. The study aims to understand changes in secondary bile acid production, gut microbiome, circulating biomarkers, and gene expression related to bile acid receptors in the colon, which may influence colorectal cancer risk. It is a prospective, single-arm clinical trial supported by the National Cancer Institute. Participants will follow a self-regulated dietary intervention for four weeks, increasing plant-based food intake while reducing animal-based food consumption. The study includes an initial visit before the diet change, a one-week observation period to record baseline food intake, the four-week dietary intervention with guidance via phone calls, and a final visit after completing the intervention. During the intervention, participants will maintain food diaries every two days, collect stool samples weekly, and report body weight weekly. Participants will attend two clinical research visits for collection of questionnaires, blood samples, and stool samples before and after the dietary intervention. Researchers will evaluate changes in stool metabolomics from baseline to the final visit as the primary outcome. Secondary outcomes include changes in gut microbiome composition. The study involves monitoring diet adherence and body weight during the intervention and is expected to last about five weeks in total for each participant.

BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention