Study of Hormone Differences in the Renin-Angiotensin-Aldosterone System in Adults Undergoing Coronary Artery Bypass Surgery With or Without Heart-Lung Machine Support

What this Trial Is About

This research aims to understand whether there are differences in hormone levels related to the renin-angiotensin-aldosterone system RAAS in patients undergoing cardiac surgery with or without the use of a heart-lung machine cardiopulmonary bypass. The study focuses on the complication called vasoplegia or vasoplegic shock, which can occur after cardiac surgery and may be influenced by how the surgery is performed. It seeks to clarify the role that bypassing the lungs during surgery plays in regulating hormones that control blood vessel tension and blood pressure. The study observes two groups of patients those having coronary artery bypass graft surgery with the heart-lung machine on-pump and those without it off-pump. No specific treatments or interventions are assigned by the study instead, medical care is managed by intensive care unit physicians as usual. Blood samples will be collected before anesthesia and immediately after surgery to measure hormone levels related to RAAS. Participants will be involved during the surgical period where plasma concentrations of various RAAS hormones are measured and compared between the two surgery types. The study also monitors the occurrence of vasoplegia and the amount of vasopressors medications to raise blood pressure used within 12 hours after surgery. The total participation period encompasses the surgical procedure and immediate postoperative monitoring. This observational approach aims to provide insight into the hormonal changes linked to surgical methods and their connection to vasoplegia.

Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery