Actively Recruiting
Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
Led by Universität Münster · Updated on 2024-12-12
40
Participants Needed
2
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
CONDITIONS
Official Title
Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients undergoing on- or off-pump coronary artery bypass graft surgery
- Written informed consent
You will not qualify if you...
- Emergency surgery in the context of acute coronary syndrome
- Use of ACE-inhibitors or Angiotensin 1 (AT1)-receptor blockers not paused on the day of surgery
- Chronic kidney disease with estimated glomerular filtration rate (eGFR) below 30 ml/min/1.73m²
- Severe structural lung diseases such as asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, COPD Gold 3-4, or lung fibrosis
- Chronic pulmonary hypertension
- Pregnancy or breastfeeding
- Dependency on the investigator or employment by the responsible institution or investigator
- Persons held in an institution by legal or official order
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Deutsches Herzzentrum der Charité
Berlin, Germany, 13353
Actively Recruiting
2
University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
Münster, Germany, 48149
Actively Recruiting
Research Team
A
Alexander Zarbock, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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