Actively Recruiting
Early Onset Colorectal Cancer Detection
Led by City of Hope Medical Center · Updated on 2026-01-28
400
Participants Needed
13
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)
CONDITIONS
Official Title
Early Onset Colorectal Cancer Detection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with stage I, II, III, or IV colorectal cancer before age 50
- Completed standard diagnostic and staging procedures and provided at least one sample before any curative treatment
- Cancer-free confirmed by colonoscopy at study entry (for non-disease controls)
You will not qualify if you...
- Having hereditary colorectal cancer syndromes identified by genetic testing
- Having inflammatory bowel diseases
- Not providing written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
2
IRCCS San Raffaele
Milan, Italy
Actively Recruiting
3
Kawasaki University
Kawasaki, Japan
Actively Recruiting
4
Mie University
Mie, Japan
Actively Recruiting
5
National Cancer Center Hospital
Tokyo, Japan
Actively Recruiting
6
Tokyo Medical and Dental University
Tokyo, Japan
Actively Recruiting
7
Yamagata University
Yamagata, Japan
Actively Recruiting
8
Barcelona University
Barcelona, Spain
Actively Recruiting
9
Colorectal Surgery, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona UAB
Barcelona, Spain
Actively Recruiting
10
Surgery Department, Hospital del Mar, Barcelona, Spain
Barcelona, Spain
Actively Recruiting
11
Salamanca Biomedical Research Institute
Madrid, Spain
Actively Recruiting
12
University of Salamanca-SACYL-CSIC, Salamanca, Spain
Salamanca, Spain
Actively Recruiting
13
University of La Laguna
San Cristóbal de La Laguna, Spain
Actively Recruiting
Research Team
A
Ajay Goel, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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