International Study Comparing Left Ventricular Unloading Strategies in Patients Receiving Venoarterial Extracorporeal Life Support

What this Trial Is About

This research aims to collect and analyze clinical data from patients receiving veno-arterial extracorporeal life support VA ECLS in intensive care units worldwide. It focuses on understanding left ventricular LV overload and comparing different methods to unload the LV during VA ECLS. The study addresses the serious conditions of cardiogenic shock and cardiac arrest, which have high mortality rates, and aims to clarify the best strategies for LV unloading to support heart function recovery. The study observes patients who have undergone implantation of VA ECLS, a procedure that supports heart and lung function by circulating blood outside the body. Researchers will document and compare various LV unloading techniques used in standard care across multiple centers, without adding extra interventions. Data on timing, types, and methods of unloading will be collected, along with clinical and radiological information before and after unloading. Participants demographic, clinical, instrumental, and laboratory data will be gathered before and after VA ECLS implantation. Researchers will assess outcomes such as in-hospital mortality at 30 days, echocardiographic measures of LV overload and unloading effectiveness, major adverse events, LV function, and neurological status at discharge. The study is prospective and observational, with no additional treatments beyond usual care, and will follow patients up to 30 days after the procedure.

ECMO LEft Ventricle UNloading Strategy