Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises

What this Trial Is About

Researchers are studying adults with classical Phenylketonuria (PKU) to understand how different types of meals before exercise affect plasma amino acid levels and metabolic control. This study aims to find the best dietary recommendations before aerobic and resistance exercises for patients with PKU, a rare metabolic disorder. It is the first study to evaluate these effects in detail, including hormonal responses and metabolic parameters during exercise. Participants will consume one of three test diets: water only, carbohydrates only, or a mixture of amino acids and carbohydrates. They will perform 30 minutes of either aerobic exercise on a treadmill or resistance exercises including crunches, push-ups, lunges, and squats. Each participant will complete six exercise sessions over six weeks with one week between sessions, alternating the type of exercise and pre-exercise meal. The study uses a randomized design and closely monitors the effects of these meals and exercises. Throughout the study, blood samples will be collected before, during, and after exercise to measure plasma amino acids such as phenylalanine, tyrosine, and branched-chain amino acids, along with glucose, insulin, lactate, blood urea nitrogen, and creatinine levels. Assessments include an initial EKG and exercise conditioning evaluation. Participants will visit the hospital on six different days, each separated by a week, for these measurements. The study's primary outcome is the change in plasma phenylalanine levels, with several other metabolic parameters measured as secondary outcomes.

Effect of Different Meal Types Given Before Exercise on Plasma Amino Acid Levels and Metabolic Control Parameters in Classical Phenylketonuria Patients Undergoing Aerobic and Resistance Exercises