Actively Recruiting
Effect of Ilex Paraguariensis Harvest Time and Consumption Method of Processed Yerba Mate on the Lipid Profile of Consumers in Caaguazu, Paraguay
Led by Universidad Nacional de Caaguazu · Updated on 2026-04-16
198
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
Universidad Nacional de Caaguazu
Lead Sponsor
H
Hospital Nacional de Itaugua, MSPyBS, Paraguay)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating how the harvest time of Ilex paraguariensis, commonly known as yerba mate, and its mode of consumption (mate, tereré, or both) affect the lipid profile of regular yerba mate consumers in the Department of Caaguazú, Paraguay. Yerba mate contains bioactive compounds like polyphenols, xanthines, and saponins. This triple-blind randomized clinical trial aims to fill the gap in knowledge about how harvest timing and consumption methods influence dyslipidemias in this population. Participants will be divided into groups based on whether they consume yerba mate harvested at the beginning or end of the harvest period and by how they consume it (mate only, tereré only, or both). The yerba mate samples will be analyzed for bioactive components before being blinded to researchers and participants. The trial includes a six-month consumption period during which participants follow prescribed consumption patterns without changing their usual diet or physical activity. During the study, the lipid profile of participants will be measured at baseline and again at 30, 90, and 180 days after starting consumption. Researchers will collect data on social, cultural, and anthropometric characteristics of consumers. Participants will know their lipid profile results only after completing the trial. The study monitors the effect of yerba mate consumption on lipid metabolism disorders over six months, with careful control of consumption and adherence.
CONDITIONS
Brief Title
Effect of Ilex Paraguariensis Harvest Time and Consumption Method of Processed Yerba Mate on the Lipid Profile
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals of both sexes, aged 18 to 60 years, living in the country and consuming prepared yerba mate.
- Regular consumers of mate, tereré, or both, willing to consume the study-provided yerba mate samples.
- Able to abstain from prepared yerba mate for two weeks before trial start.
- Willing to follow prescribed yerba mate consumption amounts and frequency without changing diet or physical activity.
- Agree to learn lipid profile results only after 180 days of consumption.
You will not qualify if you...
- Currently receiving lipid-lowering treatment at trial start.
- Consuming any yerba mate not provided by the study.
- Using vitamin supplements as nutrition.
- Taking thermogenic supplements.
- Consuming cooked mate.
- Addiction to medicinal plants or herbs including mate and tereré.
- History of coronary artery disease.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 6 months
Participants consume study-provided yerba mate as mate, tereré, or both according to their assigned group without changing their diet or physical activity.
Trial Site Locations
Total: 1 location
1
UNCA
Coronel Oviedo, Paraguay
Actively Recruiting
Research Team
J
Julieta Maria Mendez Romero
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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