Actively Recruiting
Effect of Individualized Exercise Based on Cardiopulmonary Exercise Testing on Cardiovascular Risk Factors and Heart Function in Elderly Patients with Coronary Heart Disease
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2024-12-31
200
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of individualized exercise based on cardiopulmonary exercise testing (CPET) on multiple cardiovascular risk factors and cardiopulmonary function in elderly patients with coronary heart disease. Cardiac rehabilitation, which includes medication, exercise, nutrition, psychological, and behavioral interventions, aims to improve symptoms, delay disease progression, and enhance quality of life. This comprehensive approach has been recommended by major heart associations as a key treatment for cardiovascular disease. The study compares individualized rehabilitation exercise training with optimal medical therapy. Participants in the exercise group undergo medium- and high-intensity interval training three times per week for 16 weeks, including warm-up and cooling-off periods with stretching and flexibility exercises. The control group receives routine antiplatelet and lipid-lowering drugs, dietary guidance, and restrictions on tobacco and alcohol. Exercise prescriptions are tailored based on individual physical conditions and preferences following the FITTVP principles. Participants are involved for one year, during which researchers assess various outcomes including gut microbiome, plasma metabolite profiles, six-minute walk test (6MWT), LDL cholesterol, and peak oxygen uptake (VO2peak). The study monitors physical, psychological, and social functions to evaluate improvements related to the interventions. Safety and effectiveness are followed throughout the study duration to understand the long-term impact of individualized exercise in this population.
CONDITIONS
Official Title
Effect of Individualized Exercise in Elderly Patients With Coronary Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Coronary heart disease confirmed by coronary angiography
- Age between 60 and 75 years old with stable clinical sinus rhythm
- Left ventricular ejection fraction greater than 40%
- Informed consent and voluntary participation
You will not qualify if you...
- Severe organic cardiac and lung diseases
- Hemiplegia or other physical movement disorders
- History of mental illness
- Uncontrolled hypertension or hemodynamic instability
- Severe kidney disease or severe peripheral artery disease
- Bone and joint diseases unsuitable for exercise
- Uncontrolled endocrine or other diseases
- Use of antibiotics or anti-diarrheal medications within the past 3 months
AI-Screening
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Trial Site Locations
Total: 1 location
1
the First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Actively Recruiting
Research Team
L
Leilei Chen
M
Mei Wang
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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