Actively Recruiting
Clinical and Basic Research on the Treatment of Senile Atherosclerosis and Coronary Heart Disease With Yiyang Huoluo Decoction
Led by Xia Liang · Updated on 2026-03-25
30
Participants Needed
1
Research Sites
28 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether Yiyang Huoluo Decoction, a custom Chinese herbal medicine, is safe and effective in treating coronary heart disease with atherosclerosis in older adults. The study aims to see if adding this herbal treatment to standard Western heart medications improves symptoms and heart health, and how it affects blood vessel repair at the cellular level. The trial is led by Xia Liang and focuses on adults aged 50 to 75 diagnosed with stable angina and coronary artery disease. Participants will be randomly assigned to one of two groups: one group receives standard Western medications alone, including antiplatelet drugs, statins, beta-blockers, and ACEI/ARB agents, while the other group receives these medications plus a 12-week course of Yiyang Huoluo Decoction herbal granules. Both groups continue their medication treatment for 36 weeks. This design allows researchers to compare the combined treatment versus standard care alone. During the study, participants will attend scheduled visits for health evaluations including symptom assessments, blood tests, heart and blood vessel scans such as carotid ultrasound and coronary CTA, and blood sample collection for research. Researchers will monitor traditional Chinese medicine syndrome scores, angina severity, and the incidence of in-stent restenosis over 36 weeks. Safety and adverse events will also be tracked. Participation is voluntary and personal health information is kept confidential.
CONDITIONS
Brief Title
A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the diagnostic criteria for stable angina pectoris
- Classified as Grade I to III on the Canadian Cardiovascular Society Angina Grading Scale
- Meet the diagnostic criteria for chest discomfort syndrome due to yang qi deficiency and decline
- Aged between 50 and 75 years old
- Received drug-eluting stent implantation for severe vascular stenosis (single artery ≥75%, or left main artery ≥50%)
- Able to follow medical instructions and voluntarily sign informed consent
You will not qualify if you...
- Diagnosed with acute coronary syndrome including myocardial infarction or unstable angina
- Chest pain caused by non-cardiac diseases or severe hypertension (systolic ≥180 mmHg or diastolic ≥110 mmHg)
- Severe cardiopulmonary insufficiency or malignant tumor
- Severe endocrine, blood, immune system diseases, severe liver or kidney dysfunction, active gastrointestinal bleeding, or mental illness
- Allergic to traditional Chinese medicine or have history of allergic reactions
- Incomplete major baseline data or recent participation in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 36 weeks
Participants receive either Yiyang Huoluo Decoction combined with conventional western medicine treatment, or only conventional western medicine treatment for coronary heart disease.
Visits at baseline, 12 weeks, and 36 weeks for assessments
Trial Site Locations
Total: 1 location
1
People's Hospital of Anji
Huzhou, Zhejiang, China
Actively Recruiting
Research Team
L
Liang Xia, Doctor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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