Study of Yiyang Huoluo Decoction Combined with Western Medicine to Treat Coronary Heart Disease and Atherosclerosis in Older Adults

What this Trial Is About

Researchers are evaluating whether Yiyang Huoluo Decoction, a custom Chinese herbal medicine, is safe and effective in treating coronary heart disease with atherosclerosis in older adults. The study aims to see if adding this herbal treatment to standard Western heart medications improves symptoms and heart health, and how it affects blood vessel repair at the cellular level. The trial is led by Xia Liang and focuses on adults aged 50 to 75 diagnosed with stable angina and coronary artery disease. Participants will be randomly assigned to one of two groups one group receives standard Western medications alone, including antiplatelet drugs, statins, beta-blockers, and ACEIARB agents, while the other group receives these medications plus a 12-week course of Yiyang Huoluo Decoction herbal granules. Both groups continue their medication treatment for 36 weeks. This design allows researchers to compare the combined treatment versus standard care alone. During the study, participants will attend scheduled visits for health evaluations including symptom assessments, blood tests, heart and blood vessel scans such as carotid ultrasound and coronary CTA, and blood sample collection for research. Researchers will monitor traditional Chinese medicine syndrome scores, angina severity, and the incidence of in-stent restenosis over 36 weeks. Safety and adverse events will also be tracked. Participation is voluntary and personal health information is kept confidential.

A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease