Randomized Trial on Leukocyte and Platelet Rich Fibrin Use in Dental Implant Placement and Its Effect on Implant Stability and Bone Levels

What this Trial Is About

This research investigates the impact of Leukocyte and Platelet Rich Fibrin L-PRF on the stability of dental implants and the levels of bone surrounding them. The study compares the use of L-PRF during implant placement to traditional implant placement methods. L-PRF is a fibrin mesh rich in growth factors that may improve healing, bone growth, and implant integration, but high-quality evidence in humans, especially in the jawbone, is limited. This trial aims to provide clearer clinical evidence to help dentists decide whether to use L-PRF for better implant stability and earlier implant loading. Participants will be randomly assigned to one of two groups one receiving standard implant placement with L-PRF applied to the implant site, and the other receiving standard implant placement without L-PRF. L-PRF is prepared by centrifuging the participants blood to form a fibrin clot, which is then placed around the implant during surgery. This additional step aims to enhance bone healing and implant integration. The study will take place at the Dublin Dental University Hospital and include implants placed in both the upper maxilla and lower mandible jaws. Participants will be monitored over several months with evaluations at baseline, 3 months, and between 4 to 6 months after implant placement. Assessments include measuring implant stability using an implant stability quotient, as well as clinical and radiographic evaluations of bone levels around the implant. Pain levels will also be recorded shortly after surgery and during the first week. Participants will maintain a symptom diary and attend scheduled appointments to monitor progress and safety throughout the study period, which extends until September 2026.

Effect of L-PRF on Implant Stability and Marginal Bone Levels.