Actively Recruiting
Effect of Metformin on Healthy Live Birth in Women With Prediabetes
Led by Shandong University · Updated on 2024-05-29
988
Participants Needed
1
Research Sites
201 weeks
Total Duration
On this page
Sponsors
S
Shandong University
Lead Sponsor
R
Ren Ji Hospital of Shanghai Jiao Tong University
Collaborating Sponsor
AI-Summary
What this Trial Is About
To evaluate the efficacy and safety of metformin pretreatment on reproductive outcomes in infertile women with prediabetes.
CONDITIONS
Official Title
Effect of Metformin on Healthy Live Birth in Women With Prediabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women diagnosed with prediabetes by ADA criteria, including IFG, IGT, or HbA1C 5.7-6.4%
- Women aged 20 to 40 years
- Women planning to undergo a new cycle of IVF, ICSI, or PGT-A
You will not qualify if you...
- Women diagnosed with diabetes by ADA criteria (fasting plasma glucose ≥7.0 mmol/L, 2-hour plasma glucose ≥11.1 mmol/L, HbA1c ≥6.5%, or random plasma glucose ≥11.1 mmol/L)
- Women taking medicines that affect glucose metabolism (e.g., metformin, oral anti-diabetic agents, weight loss drugs, glucocorticoids, growth hormones) within 2 months before enrollment
- Women with untreated hyperthyroidism or hypothyroidism
- Women with congenital or acquired abnormal uterine cavity (e.g., septate uterus, unicornous uterus, uterus duplex, intrauterine adhesions)
- Women diagnosed with adenomyosis
- Women with untreated hydrosalpinx
- Women planning to undergo PGT-SR or PGT-M
- Women with major medical comorbidities such as known liver disease, renal disease, or significant anemia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shandong University
Jinan, Shandong, China
Actively Recruiting
Research Team
Z
Zi-Jiang Chen, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here