Actively Recruiting
Effect of Physical Activity Pattern on Cardiometabolic Health
Led by Brigham and Women's Hospital · Updated on 2025-06-13
26
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
B
Brigham and Women's Hospital
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how the body's internal clock, called the circadian system, interacts with physical activity to influence health factors like blood sugar, blood pressure, and energy use. The study aims to find out if timing physical activity according to this internal clock can improve heart and metabolic health. This research focuses on adults aged 18 to 45 without major health conditions, exploring ways to enhance the benefits of exercise. Participants will take part in two inpatient stays during which they will perform moderate exercise under two different patterns: one group will do Exercise A first followed by Exercise B, and the other group will do Exercise B first then Exercise A. Meals provided during the stays will be identical to control food intake. Blood samples will be taken frequently, along with urine and saliva collections, to monitor various health markers affected by exercise and circadian rhythms. Throughout the study, researchers will measure outcomes such as glucose levels and blood pressure over 24 hours after exercise. They will also assess insulin sensitivity, beta-cell function, total peripheral resistance, and autonomic nervous system activity at several time points. The study includes detailed monitoring during inpatient stays and aims to better understand how exercise timing influences cardiometabolic health over the study period, which starts in October 2024 and ends in August 2026.
CONDITIONS
Brief Title
Effect of Physical Activity Pattern on Cardiometabolic Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years
- Body mass index (BMI) between 18.5 and 34.9 kg/m2
- No acute, chronic, or debilitating medical conditions such as metabolic, cardiovascular, respiratory, neurological diseases, or cancer
- Willing to follow the study protocol for the entire duration
You will not qualify if you...
- Current smoking or vaping, or history of smoking/vaping for 5 or more years
- Currently pregnant or breastfeeding
- History of drug or alcohol dependency
- History of psychiatric illness or disorder
- Any hospitalization due to COVID-19
- Unable to perform exercise for any reason
- Any known reason not to do exercise testing based on ACSM guidelines
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of both exercise interventions as specified by the study protocol
Participants undergo two different exercise interventions in a randomized crossover design to test effects on cardiometabolic health.
Multiple visits to complete both exercise conditions
Duration - 24 hours after each exercise intervention
Participants are monitored after each exercise intervention during 24-hour test periods to assess glucose levels, blood pressure, and other health markers.
1 visit (24-hour monitoring) after each intervention
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
J
Jingyi Qian, PhD
V
Vy Nguyen, B.S.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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