Study on How Physical Activity Patterns Affect Heart and Metabolic Health in Adults Ages 18 to 45

What this Trial Is About

Researchers are investigating how the bodys internal clock, called the circadian system, interacts with physical activity to influence health factors like blood sugar, blood pressure, and energy use. The study aims to find out if timing physical activity according to this internal clock can improve heart and metabolic health. This research focuses on adults aged 18 to 45 without major health conditions, exploring ways to enhance the benefits of exercise. Participants will take part in two inpatient stays during which they will perform moderate exercise under two different patterns one group will do Exercise A first followed by Exercise B, and the other group will do Exercise B first then Exercise A. Meals provided during the stays will be identical to control food intake. Blood samples will be taken frequently, along with urine and saliva collections, to monitor various health markers affected by exercise and circadian rhythms. Throughout the study, researchers will measure outcomes such as glucose levels and blood pressure over 24 hours after exercise. They will also assess insulin sensitivity, beta-cell function, total peripheral resistance, and autonomic nervous system activity at several time points. The study includes detailed monitoring during inpatient stays and aims to better understand how exercise timing influences cardiometabolic health over the study period, which starts in October 2024 and ends in August 2026.

Effect of Physical Activity Pattern on Cardiometabolic Health