Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients

What this Trial Is About

Acute kidney injury (AKI) is a common and serious condition in critically ill patients, often leading to longer intensive care stays, the need for dialysis, and higher risk of death. This research evaluates whether critically ill patients with AKI who receive a higher protein intake (more than 1.2 grams per kilogram per day) have different outcomes compared to those receiving standard or lower protein intake (1.2 grams/kg/day or less). The study uses a retrospective design to analyze existing patient data from multiple hospitals in Argentina. Patients are classified into two groups based on their protein intake recorded on the fifth day of ICU admission: one group with standard protein intake (1.2 g/kg/day or less) and another with high protein intake (greater than 1.2 g/kg/day). No new treatments or interventions are given as part of the study; it involves reviewing medical records from patients who received exclusive enteral or parenteral nutrition. The study focuses on adults aged 18 and older with AKI or worsening chronic kidney disease according to specific criteria. Participants' kidney function recovery time within 30 days is the primary outcome, measured by a return of creatinine levels close to baseline. Secondary outcomes include changes in blood urea levels, duration of renal replacement therapy, length of ICU stay, and 30-day mortality. Advanced statistical methods will adjust for differences between groups to fairly compare outcomes. The study involves no direct participant procedures and uses only de-identified retrospective data, with confidentiality maintained according to local laws.

Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.