Personalized Ciprofol and Remifentanil Anesthesia to Reduce Low Blood Pressure During Laparoscopic Surgery in Older Adults

What this Trial Is About

Elderly patients undergoing surgery often face increased risks due to age-related health changes like vascular stiffening, heart problems, and sensitivity to anesthesia, which can lead to complications such as low blood pressure during surgery. This study evaluates whether adjusting anesthesia doses based on patient responses, rather than fixed doses, can reduce these risks in older adults having laparoscopic abdominal surgery. The trial compares two anesthesia strategies using ciprofol and remifentanil drugs. One group receives anesthesia with fixed doses adjusted by routine clinical judgment, while the other group receives a titrated approach where doses are carefully adjusted using brain activity monitoring BIS to maintain a target sedation level. Both groups undergo anesthesia induction, maintenance, and surgery with close monitoring. Participants will be monitored during surgery for blood pressure and heart function, with various measurements taken to assess the incidence and severity of low blood pressure, drug doses used, recovery time, and postoperative complications including delirium and mortality up to 30 days after surgery. The study collects detailed data during and after surgery to evaluate the effects of the anesthesia methods on patient safety and recovery.

Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial