Effect of Titrated Administration of Ciprofol Combined With Remifentanil on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial

What this Trial Is About

This trial focuses on elderly patients undergoing laparoscopic abdominal surgery who often face higher risks of complications due to age-related health issues and increased sensitivity to anesthetic drugs. It evaluates whether adjusting anesthesia doses based on patient response during surgery can reduce low blood pressure and improve recovery compared to fixed-dose anesthesia protocols. The study assesses the impact of titrated anesthesia using ciprofol combined with remifentanil to manage perioperative hypotension in this vulnerable population. Participants are randomly assigned to one of two groups. One group receives anesthesia with fixed doses of ciprofol and remifentanil adjusted by clinical judgment without preset targets, while the other group receives titrated anesthesia guided by continuous monitoring of brain activity (BIS) to maintain a target level of sedation. Both induction and maintenance phases are covered, with drug doses tailored to individual responses. The trial compares these methods during the entire surgery period. During the study, patients will be closely monitored for blood pressure and heart function from the start of anesthesia until surgery ends, up to six hours. Researchers will track the occurrence and severity of low blood pressure episodes, medication doses used, time to awakening, and postoperative complications including delirium and hospital readmission. The follow-up period extends to 30 days after surgery to evaluate safety and recovery outcomes, ensuring comprehensive assessment of the anesthesia strategies.

Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial