Actively Recruiting
Prospective Randomized Controlled Trial on the Effects of Almond on Facial Skin Collagen and Wrinkles
Led by Integrative Skin Science and Research · Updated on 2024-06-18
60
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how eating almonds affects skin health, focusing on collagen production, elastin levels, wrinkles, and pigmentation in both premenopausal and postmenopausal women across all Fitzpatrick skin types. This study explores the potential skin benefits of almonds, which are rich in nutrients like vitamin E and polyphenols known to combat oxidative stress and have shown benefits in previous clinical studies for skin aging and protection. Participants will be randomly assigned to consume either 60 grams (about 2 ounces) of whole almonds or a protein- and calorie-matched non-nut snack five times per week. The study lasts for 24 weeks, during which the effects on facial skin collagen, elastin, wrinkle severity, pigmentation, and related enzymes will be measured. Both groups will maintain their usual skincare routines and diets throughout the study. During the 24 weeks, participants will have their skin collagen and elastin levels quantified, wrinkle severity assessed, and pigmentation scored. Skin biopsies will be analyzed for enzymes that affect collagen breakdown and preservation, and blood samples will be collected to study advanced glycation end products. The study includes safety monitoring and aims to understand the detailed impact of almond consumption on skin aging in women aged 35 to 70 years.
CONDITIONS
Brief Title
The Effects of Almond on Facial Skin Collagen and Wrinkles
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 35 to 70 years of all skin types
- 50% of participants will be postmenopausal women, defined as more than 1 year without a menstrual period
- 50% of participants will be premenopausal women
- Body mass index between 18.5 and 35 kg/m2
- Stable habitual diet maintained for at least 6 months and to be maintained during the study
- Usual skincare products used for at least 1 month and maintained throughout the study
You will not qualify if you...
- Allergy to nuts
- Unwillingness to stop oral collagen supplements 1 month before the study
- Unwillingness to stop vitamin E or nut-containing supplements 2 weeks before and during the study
- Pregnancy or breastfeeding
- Changes in skincare products during the study
- Medical or cosmetic facial procedures like laser resurfacing, plastic surgery, botulinum toxin, dermal fillers, or collagen treatments within the last 6 months
- Autoimmune photosensitive conditions or genetic collagen deficiency disorders such as Ehler-Danlos syndrome
- Skin diseases on the face affecting skin assessment
- Current tobacco smoking or a history of over 10 pack-years smoking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 24 weeks
Participants consume either 60 grams of whole almonds or a protein and calorie matched non-nut snack 5 times per week to evaluate effects on facial skin collagen and wrinkles.
Weekly visits for 24 weeks
Trial Site Locations
Total: 1 location
1
Integrative Skin Science and Research
Sacramento, California, United States, 95819
Actively Recruiting
Research Team
S
Sarah Adnan
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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